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Volume 27, Number 3—March 2021
CME ACTIVITY - Research

Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan

Amyn A. MalikComments to Author , Neel R. Gandhi, Timothy L. Lash, Lisa M. Cranmer, Saad B. Omer, Junaid F. Ahmed, Sara Siddiqui, Farhana Amanullah, Aamir J. Khan, Salmaan Keshavjee, Hamidah Hussain1, and Mercedes C. Becerra1
Author affiliations: Emory University Rollins School of Public Health, Atlanta, Georgia, USA (A.A. Malik, N.R. Gandhi, T.L. Lash); Yale University, New Haven, Connecticut, USA (A.A. Malik, S.B. Omer); Global Health Directorate, Indus Health Network, Karachi, Pakistan (A.A. Malik, J.F. Ahmed, S. Siddiqui); Interactive Research and Development, Singapore (A.A. Malik, A.J. Khan, H. Hussain); Emory University School of Medicine, Atlanta (N.R. Gandhi, L.M. Cranmer); Emory + Children’s Pediatric Institute, Atlanta (L.M. Cranmer); The Indus Hospital, Karachi (F. Amanullah); Harvard University, Cambridge, Massachusetts, USA (A.J. Khan, S. Keshavjee, M.C. Becerra); Partners In Health, Boston, Massachusetts, USA (S. Keshavjee, M.C. Becerra); Brigham and Women’s Hospital, Boston (S. Keshavjee, M.C. Becerra)

Main Article

Table 4

Incidence rate comparison of effectiveness of preventive therapy for tuberculosis in published studies in study of persons exposed at home to drug-resistant tuberculosis, Karachi, Pakistan*

Characteristic Becerra et al. (25) Fox et al. (22) Reichler et al. (26) Martin-Sanchez et al. (27)
No. expected cases 4.7 3.9 6.6 6.6
Expected IR per 1,000 p-y 15 12 20 20
IRR (95% CI) 0.40 (0.05–2.0) 0.50 (0.06–2.8) 0.29 (0.04–1.3) 0.29 (0.04–1.3)
IR difference per 1,000 p-y (95% CI) −8.0 (–23.0 to 7.1) −5.7 (–20.0 to 8.5) −14 (–31.0 to 3.4) −14 (–31.0 to 3.4)
NNT 64 91 37 37
Preventive fraction in exposed, % 57.5 48.7 69.5 69.7

*IR, incidence rate; IRR, incidence rate ratio; NNT, number needed to treat; p-y, person-years.

Main Article

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1These authors contributed equally to this article.

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