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Volume 27, Number 3—March 2021

Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014–2017

Ditthawat Nonghanphithak, Angkana Chaiprasert, Saijai Smithtikarn, Phalin Kamolwat, Petchawan Pungrassami, Virasakdi Chongsuvivatwong, Surakameth Mahasirimongkol, Wipa Reechaipichitkul, Chaniya Leepiyasakulchai, Jody E. Phelan, David Blair, Taane G. Clark, and Kiatichai FaksriComments to Author 
Author affiliations: Khon Kaen University, Khon Kaen, Thailand (D. Nonghanphithak, W. Reechaipichitkul, K. Faksri); Mahidol University, Bangkok, Thailand (A. Chaiprasert, C. Leepiyasakulchai); Ministry of Public Health, Bangkok (S. Smithtikarn, P. Kamolwat, P. Pungrassami); Prince of Songkla University, Hat Yai, Songkhla, Thailand (V. Chongsuvivatwong); Ministry of Public Health, Nonthaburi, Thailand (S. Mahasirimongkol); London School of Hygiene and Tropical Medicine, London, UK (J.E. Phelan, T.G. Clark); James Cook University, Townsville, Queensland, Australia (D. Blair)

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Table 1

Characteristics of isolates within 89 DR TB clusters, Thailand, 2014–2017*

Clustered isolates, n = 281 DR TB types, no. (%)†
INH-R, n = 11 MDR TB, n = 205 Pre-XDR TB, n = 46 XDR TB, n = 19
Possible primary DR TB,‡ n = 230, 81.85% 11 (100.0) 176 (85.85) 29 (63.04) 14 (73.68)
Possible acquired DR TB,‡ n = 51, 18.15% 0 29 (14.15) 17 (36.96) 5 (26.32)

*Using a pairwise-difference range of 0–11 single nucleotide polymorphisms, 89 clusters (minimum cluster size = 2 isolates) were recognized. DR, drug-resistant; INH-R, isoniazid resistant; MDR, multidrug-resistant; TB, tuberculosis; XDR, extensively drug-resistant.
†DR TB types based on genotypic drug susceptibility tests.
‡Possible primary DR TB isolates were differentiated from acquired DR TB isolates based on the acquisition of mutations associated with DR TB and from co-ancestral relationships.

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Page created: December 29, 2020
Page updated: February 21, 2021
Page reviewed: February 21, 2021
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