TY - JOUR AU - Nonghanphithak, Ditthawat AU - Chaiprasert, Angkana AU - Smithtikarn, Saijai AU - Kamolwat, Phalin AU - Pungrassami, Petchawan AU - Chongsuvivatwong, Virasakdi AU - Mahasirimongkol, Surakameth AU - Reechaipichitkul, Wipa AU - Leepiyasakulchai, Chaniya AU - Phelan, Jody AU - Blair, David AU - Clark, Taane AU - Faksri, Kiatichai T1 - Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014–2017 T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 3 SP - 813 SN - 1080-6059 AB - Multidrug-resistant tuberculosis (MDR TB), pre-extensively drug-resistant tuberculosis (pre-XDR TB), and extensively drug-resistant tuberculosis (XDR TB) complicate disease control. We analyzed whole-genome sequence data for 579 phenotypically drug-resistant M. tuberculosis isolates (28% of available MDR/pre-XDR and all culturable XDR TB isolates collected in Thailand during 2014–2017). Most isolates were from lineage 2 (n = 482; 83.2%). Cluster analysis revealed that 281/579 isolates (48.5%) formed 89 clusters, including 205 MDR TB, 46 pre-XDR TB, 19 XDR TB, and 11 poly–drug-resistant TB isolates based on genotypic drug resistance. Members of most clusters had the same subset of drug resistance-associated mutations, supporting potential primary resistance in MDR TB (n = 176/205; 85.9%), pre-XDR TB (n = 29/46; 63.0%), and XDR TB (n = 14/19; 73.7%). Thirteen major clades were significantly associated with geography (p<0.001). Clusters of clonal origin contribute greatly to the high prevalence of drug-resistant TB in Thailand. KW - Mycobacterium tuberculosis KW - drug resistance KW - multidrug-resistant TB KW - transmission KW - whole-genome sequencing KW - Thailand KW - bacteria KW - antimicrobial resistance KW - tuberculosis and other mycobacteria DO - 10.3201/eid2703.204364 UR - https://wwwnc.cdc.gov/eid/article/27/3/20-4364_article ER - End of Reference