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Volume 27, Number 4—April 2021
Research

Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci

Mingliang Chen1Comments to Author , Odile B. Harrison1, Holly B. Bratcher, Zhiyan Bo, Keith A. Jolley, Charlene M.C. Rodrigues, James E. Bray, Qinglan Guo, Xi Zhang, Min ChenComments to Author , and Martin C.J. MaidenComments to Author 
Author affiliations: Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China (M. Chen, X. Zhang, M. Chen); University of Oxford, Oxford, UK (O.B. Harrison, H.B. Bratcher, Z. Bo, K.A. Jolley, C.M.C. Rodrigues, J.E. Bray, M.C.J. Maiden); Fudan University, Huashan Hospital, Shanghai (Q. Guo)

Main Article

Table 2

Specific alleles of antigenic genes in 4 sublineages of clonal complex 4821 of Neisseria meningitidis

Sublineage Antigen allele no. (no. isolates)
PorA fHbp nhba PorB FetA-VR opcA nspA tbpA NMB-0315
L44.1, n = 50 P1.7–2,14 (25) 22 (12) 124 (48) 3–48 (47) F3–3 (45) None 4 (49) 7 (36) None
P1.12–1,16–8 (9) 489 (13)
498 (15)
L44.2, n = 29 None None 965 (10) 3–81 (15) F1–91 (20) None None None 335 (26)
967 (12)
L44.3, n = 58 P1.17–6,23-x* (23) None None 3–229 (35) F3–9 (8) 100 (40) 26 (39) 1,333 (31) 194 (49)
F3–36 (37)
L44.4, n = 32 P1.5–3,10–2 (8) None None 3–460 (7) F1–7 (11) None 117 (20) None None

*23-x refers to 23, 23–2, and 23–6.

Main Article

1These authors contributed equally to this article.

Page created: March 02, 2021
Page updated: March 18, 2021
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