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Volume 27, Number 4—April 2021

Genomic Characterizations of Clade III Lineage of Candida auris, California, USA

Travis K. Price, Ruel Mirasol, Kevin W. Ward, Ayrton J. Dayo, Evann E. Hilt, Sukantha Chandrasekaran, Omai B. Garner, Annabelle de St Maurice, and Shangxin YangComments to Author 
Author affiliation: University of California, Los Angeles, California, USA

Main Article

Table 1

Characteristics of patients with Candida auris infection, Los Angeles, California, USA, 2019–2020*

Patient Date of
positive PCR Cycle threshold C. auris isolate (specimen type) Approximate age, y Clinical history Current signs, symptoms, and diagnosis
2019 Oct 8
UCLA_A1 (inguinal–axillary); UCLA_A2 (tracheal, deemed colonization)
Coronary artery disease, stroke, chronic respiratory fracture, tracheostomy and ventilator dependence, gastrostomy tube dependence, urinary incontinence, multiple ulcers, heart failure, atrial fibrillation, and previous carbapenem-resistant Enterobacteriaceae bacteremia. This patient had a prior history of C. auris colonization at the long-term acute-care facility.
Septic shock caused by methicillin-resistant Staphylococcus aureus bacteremia and multifocal pneumonia. C. auris, Candida albicans, and Candida parapsilosis were isolated from tracheal suction culture.
2020 July 28
Not isolated†
Anoxic brain injury caused by MRSA endocarditis and pulseless electrical activity arrest, stroke, and gastrostomy tube dependence.
Hemoptysis, upper gastrointestinal bleeding, hypotension, and tachycardia. MRSA, Escherichia coli, Providencia stuartii, Proteus mirabilis, and Acinetobacter baumanii grew on blood cultures. Candida glabrata grew on lower respiratory culture.
2020 Aug 12
UCLA_C1 (inguinal–axillary)
Hypertension, hyperlipidemia, intracranial hemorrhage and ventriculoperitoneal shunt, tracheostomy, and gastrostomy tube dependence.
Respiratory failure caused by pulmonary edema. P. mirabilis grew on urine cultures.
2020 Aug 19
UCLA_D1 (inguinal–axillary)
Hypertension, hyperlipidemia, type 2 diabetes, aplastic anemia, stroke, pulmonary embolism, pneumothorax, and coronavirus disease–related pneumonia causing respiratory failure, tracheostomy, and gastrostomy tube dependence.
Elevated liver enzymes and gastrointestinal bleeding complicated by Enterococcus bacteremia and E. coli urinary tract infection.
2020 Aug 31
UCLA_E1 (inguinal–axillary)
Hypertension, hyperlipidemia, tracheostomy, and gastrostomy tube dependence.
Worsening generalized weakness possibly caused by chronic intermittent demyelinating polyneuropathy.
F 2020 Sep 3 30.6 UCLA_F1 (pleural fluid, active infection) 85 Subarachnoid hemorrhage, tracheostomy, gastrostomy tube dependence, stage IV sacral decubitus ulcer, and chronic kidney disease. This patient had a prior history of C. auris colonization at the long-term acute-care facility. Bronchopulmonary fistula. C. auris, Pseudomonas aeruginosa, and Enterococcus faecalis grew on pleural fluid cultures.

*MRSA, methicillin-resistant Staphylococcus aureus.
†C. auris was not isolated from the inguinal–axillary surveillance swab of patient B.

Main Article

Page created: March 11, 2021
Page updated: March 18, 2021
Page reviewed: March 18, 2021
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