Volume 27, Number 4—April 2021
Genomic Characterizations of Clade III Lineage of Candida auris, California, USA
|Patient||Date of positive PCR||Cycle threshold||C. auris isolate (specimen type)||Approximate age, y||Clinical history||Current signs, symptoms, and diagnosis|
||2019 Oct 8
||UCLA_A1 (inguinal–axillary); UCLA_A2 (tracheal, deemed colonization)
||Coronary artery disease, stroke, chronic respiratory fracture, tracheostomy and ventilator dependence, gastrostomy tube dependence, urinary incontinence, multiple ulcers, heart failure, atrial fibrillation, and previous carbapenem-resistant Enterobacteriaceae bacteremia. This patient had a prior history of C. auris colonization at the long-term acute-care facility.
||Septic shock caused by methicillin-resistant Staphylococcus aureus bacteremia and multifocal pneumonia. C. auris, Candida albicans, and Candida parapsilosis were isolated from tracheal suction culture.
||2020 July 28
||Anoxic brain injury caused by MRSA endocarditis and pulseless electrical activity arrest, stroke, and gastrostomy tube dependence.
||Hemoptysis, upper gastrointestinal bleeding, hypotension, and tachycardia. MRSA, Escherichia coli, Providencia stuartii, Proteus mirabilis, and Acinetobacter baumanii grew on blood cultures. Candida glabrata grew on lower respiratory culture.
||2020 Aug 12
||Hypertension, hyperlipidemia, intracranial hemorrhage and ventriculoperitoneal shunt, tracheostomy, and gastrostomy tube dependence.
||Respiratory failure caused by pulmonary edema. P. mirabilis grew on urine cultures.
||2020 Aug 19
||Hypertension, hyperlipidemia, type 2 diabetes, aplastic anemia, stroke, pulmonary embolism, pneumothorax, and coronavirus disease–related pneumonia causing respiratory failure, tracheostomy, and gastrostomy tube dependence.
||Elevated liver enzymes and gastrointestinal bleeding complicated by Enterococcus bacteremia and E. coli urinary tract infection.
||2020 Aug 31
||Hypertension, hyperlipidemia, tracheostomy, and gastrostomy tube dependence.
||Worsening generalized weakness possibly caused by chronic intermittent demyelinating polyneuropathy.
|F||2020 Sep 3||30.6||UCLA_F1 (pleural fluid, active infection)||85||Subarachnoid hemorrhage, tracheostomy, gastrostomy tube dependence, stage IV sacral decubitus ulcer, and chronic kidney disease. This patient had a prior history of C. auris colonization at the long-term acute-care facility.||Bronchopulmonary fistula. C. auris, Pseudomonas aeruginosa, and Enterococcus faecalis grew on pleural fluid cultures.|
*MRSA, methicillin-resistant Staphylococcus aureus. †C. auris was not isolated from the inguinal–axillary surveillance swab of patient B.