Volume 27, Number 5—May 2021
CME ACTIVITY - Research
Characteristics and Clinical Implications of Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection, Italy
|KPC-Kp infections||No.||Died, no. (%)||HR (95% CI)†||p value||HR (95% CI)‡||p value|
|Severity of infection§|
|Mild||109||13 (11.9)||0.71 (0.40–1.27)||0.247||0.75 (0.42–1.34)||0.328|
|Bloodstream infections||176||45 (25.6)||NA||NA||NA||NA|
|Septic shock at admission|
|Y||44||20 (45.5)||2.72 (1.50–4.90)||0.0009||2.71 (1.46–5.02)||0.002|
*All patients are stratified for severity of infection; the subgroup of patients with bloodstream infection is stratified for septic shock. KPC-Kp, Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae; NA, not applicable. †Hazard ratio (HR) estimates are from multivariable Cox proportional hazard models, adjusting for center (random effect) and days elapsing from hospitalization to KPC-Kp isolation. ‡Multivariate Cox mixed effects model adjusting for center (random effect) and days elapsing from hospitalization to KPC-Kp isolation, age, Charlson Index, and whether or not isolates were collected when patient was in the intensive care unit. §Patients discharged or deceased on the day of KPC-Kp isolation were excluded from analyses; 20 patients were discharged, 9 colonized patients died, and 3 colonized patients had severe infections.
1Group collaborators are listed at the end of this article.