Longevity of Middle East Respiratory Syndrome Coronavirus Antibody Responses in Humans, Saudi Arabia
Abeer N. Alshukairi1
, Jincun Zhao1
, Maha A. Al-Mozaini, Yanqun Wang, Ashraf Dada, Salim A. Baharoon, Sara Alfaraj, Waleed A. Ahmed, Mushira A. Enani, Fatehi E. Elzein, Nazik Eltayeb, Laila Layqah, Aiman El-Saed, Husam A. Bahaudden, Abdul Haseeb, Sherif A. El-Kafrawy, Ahmed M. Hassan, Najlaa A. Siddiq, Ibtihaj Alsharif, Isamel Qushmaq, Esam I. Azhar2
, Stanley Perlman2
, and Ziad A. Memish2
Author affiliations: King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia (A.N. Alshukairi, A. Dada, N.A. Siddiq, I. Qushmaq); First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (J. Zhao, Y. Wang); King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia (M.A. Al-Moziani, I. Alsharif); King Abdulaziz Medical City, Riyadh (S.A. Baharoon, A. El-Saed); Prince Mohammed Bin Abdulaziz Hospital, Riyadh (S. Alfaraj); Security Forces Hospital, Makkah, Saudi Arabia (W.A. Ahmed); King Fahad Medical City, Riyadh (M.A. Enani); Prince Sultan Military Medical City, Riyadh (F.E. Elzein, N. Eltayeb); King Abdullah International Medical Research Center, Riyadh (L. Layqah); King Saud bin Abdulaziz University for Health Sciences, Jeddah (H.A. Bahaudden); Umm Al Qura University, Makkah, Saudi Arabia (A. Haseeb); King Abdulaziz University, Jeddah (S.A. El-Kafrawy, A.M. Hassan); King Fahd Medical Research Center, Jeddah (E.F. Azhar); University of Iowa, Iowa City, Iowa, USA (S. Perlman); King Saud Medical City, Riyadh (Z.A. Memish); Al-Faisal University, Riyadh (Z.A. Memish)
Figure. Neutralization antibody titers in Middle East respiratory syndrome (MERS) convalescent-phase serum samples measured 2–-6 years postinfection, Saudi Arabia. Three groups (patients who had mild, moderate, or severe MERS) were enrolled in this study, and serum samples were collected for neutralizing antibody detection (median focus reduction neutralization test titer) at the indicated times after recovery. The cutoff value was 1:20. Median titers of neutralizing antibody (red dots) and interquartile range (blue bars) were measured according to years postinfection (panel A) and disease severity (panel B). There was no major decrease in neutralizing antibodies over 6 years postinfection. Survivors who had moderate and severe disease had higher neutralizing antibody titers then survivors who had mild disease. Mod, moderate; Sev, severe.
Page created: February 09, 2021
Page updated: April 21, 2021
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