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Volume 27, Number 5—May 2021
Research

Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020

Philip Eisermann1, Dennis Rubbenstroth1, Daniel Cadar, Corinna Thomé-Bolduan, Petra Eggert, Alexander Schlaphof, Frank Leypoldt, Martin Stangel, Thorsten Fortwängler, Florian Hoffmann, Andreas Osterman, Sabine Zange, Hans-Helmut Niller, Klemens Angstwurm, Kirsten Pörtner, Christina Frank, Hendrik Wilking, Martin Beer, Jonas Schmidt-Chanasit, and Dennis TappeComments to Author 
Author affiliations: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany (P. Eisermann, D. Cadar, C. Thomé-Bolduan, P. Eggert, A. Schlaphof, J. Schmidt-Chanasit, D. Tappe); Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany (D. Rubbenstroth, M. Beer); University Medical Center Schleswig-Holstein, Kiel, Germany (F. Leypoldt); Medizinische Hochschule Hannover, Hannover, Germany (M. Stangel); Donau-Isar-Klinikum Deggendorf, Deggendorf, Germany (T. Fortwängler); Ludwig-Maximilians-University, Munich, Germany (F. Hoffmann); Max von Pettenkofer Institute, Munich (A. Osterman); German Center for Infection Research, Munich (A. Osterman); Bundeswehr Institute of Microbiology, Munich (S. Zange); Regensburg University Hospital, Regensburg, Germany (H.-H. Niller, K. Angstwurm); Postgraduate Training for Applied Epidemiology, Berlin, Germany (K. Pörtner); European Centre for Disease Prevention and Control, Stockholm, Sweden (K. Pörtner); Robert Koch Institute, Berlin (K. Pörtner, C. Frank, H. Wilking)

Main Article

Figure 2

Germany showing locations of residences of human case-patients who had encephalitis and other conditions and were tested for bornavirus etiology, 2018–2020. Among 103 encephalitis cases with unknown etiology, 4 bornavirus cases were found: 1 chronic VSBV-1 infection in northern Germany (case 1) and 3 BoDV-1 infections in southern Germany (cases 2, 3, and 4). Encephalitis cases without a bornavirus etiology are indicated as green circles. Among 121 cases without a clinical history of encephalitis but for whom a bornavirus serologic analysis was requested, no bornavirus infections were detected (blue circles). Purple indicates regions known to be endemic for BoDV-1. BoDV-1, Borna disease virus 1; VSBV-1, variegated squirrel bornavirus 1.

Figure 2. Germany showing locations of residences of human case-patients who had encephalitis and other conditions and were tested for bornavirus etiology, 2018–2020. Among 103 encephalitis cases with unknown etiology, 4 bornavirus cases were found: 1 chronic VSBV-1 infection in northern Germany (case 1) and 3 BoDV-1 infections in southern Germany (cases 2, 3, and 4). Encephalitis cases without a bornavirus etiology are indicated as green circles. Among 121 cases without a clinical history of encephalitis but for whom a bornavirus serologic analysis was requested, no bornavirus infections were detected (blue circles). Purple indicates regions known to be endemic for BoDV-1. BoDV-1, Borna disease virus 1; VSBV-1, variegated squirrel bornavirus 1.

Main Article

1These authors contributed equally to this article.

Page created: February 08, 2021
Page updated: April 20, 2021
Page reviewed: April 20, 2021
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