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Volume 27, Number 5—May 2021
Dispatch

Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China

Daniel K.W. Chu1, Kenrie P.Y. Hui1, Haogao Gu, Ronald L.W. Ko, Pavithra Krishnan, Daisy Y.M. Ng, Gigi Y.Z. Liu, Carrie K.C. Wan, Man-Chun Cheung, Ka-Chun Ng, John M. Nicholls, Dominic N.C. Tsang, Malik Peiris, Michael C.W. ChanComments to Author , and Leo L.M. PoonComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (D.K.W. Chu, K.P.Y. Hui, H. Gu, R.L.W. Ko, P. Krishnan, D.Y.M. Ng, G.Y.Z. Liu, C.K.C. Wan, M.-C. Cheung, K.-C. Ng, J.M. Nicholls, M. Peiris, M.C.W. Chan, L.L.M. Poon); Department of Health, Hong Kong (D.N.C. Tsang)

Main Article

Table

Amino acid differences between severe acute respiratory syndrome coronavirus 2 variants in 3 waves of coronavirus disease, Hong Kong, China*

Genome category Amino acid position Wave 1 virus
 Wave 3 virus
 Wave 4 virus
VM20001061 Case 4533 Patient A2
ORF1A/1AB
NSP2 141 M V M
NSP3 85 A V A
238 V V L
453 V I V
1,179 A A V
RdRp 323 P L L
EndoRNAse
 231
 A
 V
 A
Spike 12 S F S
25 L P P
367 F V V
614 D G G
680 Q R R
1,002
 E
 Q
 Q
ORF3a 57 Q Q H
227
 T
 T
 I
ORF3b
 14
 E
 E
 STOP
ORF8 62 L V V
84
 S
 L
 L
Nucleocapsid 12 A G A
194 S S L
203 R K R
204
 G
 R
 G
ORF9b 9 H D H

*Bold text indicates position where isolated differs from the other isolates. A, alanine; D, aspartic acid; E, envelope; F, phenylalanine; G, glycine; H, histidine; I, isoleucine; L, leucine; M, membrane; NSP, nonstructural protein; ORF, open reading frame; P, proline; Q, glutamine; R, arginine; S, spike; STOP, stop codon; T, threonine; V, valine.

Main Article

1These first authors contributed equally to this article.

Page created: February 24, 2021
Page updated: April 22, 2021
Page reviewed: April 22, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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