Novel SARS-CoV-2 Variant Derived from Clade 19B, France
, Jean-Winoc Decousser, Souraya Khouider, Melissa N’Debi, Vanessa Demontant, Elisabeth Trawinski, Aurélie Gourgeon, Christine Gangloff, Grégory Destras, Antonin Bal, Laurence Josset, Alexandre Soulier, Yannick Costa, Guillaume Gricourt, Bruno Lina, Raphaël Lepeule, Jean-Michel Pawlotsky, and Christophe Rodriguez
Author affiliations: Institut Mondor de Recherche Biomédicale, Université Paris-Est, Créteil, France; (S. Fourati, S. Khouider, A. Gourgeon, A. Soulier, J.-M. Pawlotsky, C. Rodriguez); Hôpital Henri Mondor, Créteil (J.-W. Decousser, M. N’Debi, V. Demontant, E. Trawinski, G. Gricourt, R. Lepeule, C. Rodriguez); Hôpital Albert Chenevier, Créteil (C. Gangloff); Université de Lyon, France (G. Destras, A. Bal, L. Josset, B. Lina); Grand Hôpital de l’Est Francilien, Jossigny, France (Y. Costa)
Figure. Phylogenetic tree built with sequences from the 33 patients infected with the new HMN.19B or Henri Mondor variant and from 1,537 SARS-CoV-2–infected patients in France sampled during January 18–February 23, 2021, sequenced in 9 successive series. Phylogeny was performed after full-length genome alignment with Muscle 3.8.31 (maximum-likelihood model general time-reversible plus invariant sites model, 1,000 bootstrap replicates) by means of IQ-Tree 188.8.131.52 and iTOL. The HMN.19B (Henri Mondor) variant cluster is considerably different from all the others, with a 99% bootstrap value. HMN.19B sequences are colored according to the geographic origin of the patients: red, greater Paris area (IDF or HMN); blue, southeast France (ARA); green, southwest France (NAQ). *Original cluster in an occupational health unit; **cluster in the hematology department of our institution. Amino-acid substitutions and deletions detected in all sequences are described in the orange box. ARA, Auvergne-Rhône-Alpes; HMN, Henri Mondor; IDF, Ile-de-France; NAQ, Nouvelle-Aquitaine.
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