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Volume 27, Number 5—May 2021
Research Letter

Novel SARS-CoV-2 Variant Derived from Clade 19B, France

Slim FouratiComments to Author , Jean-Winoc Decousser, Souraya Khouider, Melissa N’Debi, Vanessa Demontant, Elisabeth Trawinski, Aurélie Gourgeon, Christine Gangloff, Grégory Destras, Antonin Bal, Laurence Josset, Alexandre Soulier, Yannick Costa, Guillaume Gricourt, Bruno Lina, Raphaël Lepeule, Jean-Michel Pawlotsky, and Christophe Rodriguez
Author affiliations: Institut Mondor de Recherche Biomédicale, Université Paris-Est, Créteil, France; (S. Fourati, S. Khouider, A. Gourgeon, A. Soulier, J.-M. Pawlotsky, C. Rodriguez); Hôpital Henri Mondor, Créteil (J.-W. Decousser, M. N’Debi, V. Demontant, E. Trawinski, G. Gricourt, R. Lepeule, C. Rodriguez); Hôpital Albert Chenevier, Créteil (C. Gangloff); Université de Lyon, France (G. Destras, A. Bal, L. Josset, B. Lina); Grand Hôpital de l’Est Francilien, Jossigny, France (Y. Costa)

Main Article

Table

Amino acid changes within the spike protein sequence of the HMN.19B variant in France compared with the reference sequence of the international GISAID database (GenBank accession no. NC_045512.2), in comparison with other recently identified SARS-CoV-2 variants*

Spike protein sequence
HMN.19B
(Henri Mondor variant) 20I/501Y.V1
(UK variant) 20H/501Y.V2 (South African variant) P1 20J/501Y.V3 (Brazilian variant) CAL.20C
(Californian variant)
S13I
L18F L18F L18F
T20N
P26S
Del69/70
D80A
D138Y
Del144
W152C
R190S
D215G
Del 242–244
R246I
K417N K417T
L452R L452R
E484K E484K
N501Y N501Y N501Y N501Y
A570D
A653V
H655Y H655Y
Q677H†
P681H
A701V
T716I
D796Y
S982A
T1027I
D1118H
G1219V

*Bold type indicates amino acid changes observed in >1 of the recent variants.
†Inconstantly detected, recently found in the genome of the “Midwest” variant (Q677H variant) observed in Ohio (USA) in December 2020 and January 2021.

Main Article

Page created: March 16, 2021
Page updated: April 22, 2021
Page reviewed: April 22, 2021
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