Volume 27, Number 5—May 2021
Research Letter
Novel SARS-CoV-2 Variant Derived from Clade 19B, France
Slim Fourati
, Jean-Winoc Decousser, Souraya Khouider, Melissa N’Debi, Vanessa Demontant, Elisabeth Trawinski, Aurélie Gourgeon, Christine Gangloff, Grégory Destras, Antonin Bal, Laurence Josset, Alexandre Soulier, Yannick Costa, Guillaume Gricourt, Bruno Lina, Raphaël Lepeule, Jean-Michel Pawlotsky, and Christophe Rodriguez
, Jean-Winoc Decousser, Souraya Khouider, Melissa N’Debi, Vanessa Demontant, Elisabeth Trawinski, Aurélie Gourgeon, Christine Gangloff, Grégory Destras, Antonin Bal, Laurence Josset, Alexandre Soulier, Yannick Costa, Guillaume Gricourt, Bruno Lina, Raphaël Lepeule, Jean-Michel Pawlotsky, and Christophe Rodriguez
Table
Amino acid changes within the spike protein sequence of the HMN.19B variant in France compared with the reference sequence of the international GISAID database (GenBank accession no. NC_045512.2), in comparison with other recently identified SARS-CoV-2 variants*
| Spike protein sequence |
||||
|---|---|---|---|---|
| HMN.19B (Henri Mondor variant) | 20I/501Y.V1 (UK variant) | 20H/501Y.V2 (South African variant) | P1 20J/501Y.V3 (Brazilian variant) | CAL.20C (Californian variant) |
| S13I | ||||
| L18F | L18F | L18F | ||
| T20N | ||||
| P26S | ||||
| Del69/70 | ||||
| D80A | ||||
| D138Y | ||||
| Del144 | ||||
| W152C | ||||
| R190S | ||||
| D215G | ||||
| Del 242–244 | ||||
| R246I | ||||
| K417N | K417T | |||
| L452R | L452R | |||
| E484K | E484K | |||
| N501Y | N501Y | N501Y | N501Y | |
| A570D | ||||
| A653V | ||||
| H655Y | H655Y | |||
| Q677H† | ||||
| P681H | ||||
| A701V | ||||
| T716I | ||||
| D796Y | ||||
| S982A | ||||
| T1027I | ||||
| D1118H | ||||
| G1219V | ||||
*Bold type indicates amino acid changes observed in >1 of the recent variants. †Inconstantly detected, recently found in the genome of the “Midwest” variant (Q677H variant) observed in Ohio (USA) in December 2020 and January 2021.
Page created: March 16, 2021
Page updated: April 22, 2021
Page reviewed: April 22, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.