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Volume 27, Number 6—June 2021

Precision Tracing of Household Dengue Spread Using Inter- and Intra-Host Viral Variation Data, Kamphaeng Phet, Thailand

Irina Maljkovic Berry1Comments to Author , Melanie C. Melendrez1, Simon Pollett, Katherine Figueroa, Darunee Buddhari, Chonticha Klungthong, Ananda Nisalak2, Michael Panciera, Butsaya Thaisomboonsuk, Tao Li, Tyghe G. Vallard, Louis Macareo, In-Kyu Yoon, Stephen J. Thomas, Timothy Endy, and Richard G. Jarman
Author affiliations: Walter Reed Army Institute of Research Viral Diseases Branch, Silver Spring, Maryland, USA (I. Maljkovic Berry, M.C. Melendrez, S. Pollett, K. Figueroa, M. Panciera, T. Li, T.G. Vallard, R.G. Jarman); Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand (D. Buddhari, C. Klungthong, A. Nisalak, B. Thaisomboonsuk, L. Macareo); International Vaccine Institute, Seoul, South Korea (I.-K. Yoon); Upstate Medical University of New York Department of Medicine, Syracuse, New York, USA (S.J. Thomas, T. Endy)

Main Article

Table 1

Summary of probable household-to-household spread of dengue virus inferred by consensus genomes, Kamphaeng Phet, Thailand, 2009–2012

Serotype and sublineage Subdistrict Origin household† (location probability) Destination household (location probability) Approximate distance, m Sampling time difference, d
DENV-1, sublineage 1 LD LD02H075 (1.0) LD01H116 (1.0) 1,400 19
DENV-1, sublineage 1 SK SK06H346 (0.99) SK06H370 (1.0) 3,000 29
DENV-1, sublineage 7 TN TN18H021 (0.88) TN18H014 (1.0) 80 1
DENV-1, sublineage 7 NC NC06H057 (0.82) NC06H407 (1.0) 30 0, 14‡
DENV-2, sublineage 2 NB NB06H055 (0.80) NB06H084 (1.0) 800 13
DENV-2, sublineage 2 NP NP08H080 (0.82) NP08H044 (1.0) 180 0
DENV-2, sublineage 6 SK SK06H790 (0.99) SK06H485 (1.0) 3,000 49

*LD, Lan Dokmai; NB, Na Bo Kham; NC, Nakhon Chum; NP, Nong Pling; SK, Sa Kaeo; TN, Thep Nakhon.
†Households are described by their subdistrict, cluster, and house numbers, such that the first 2 letters denote subdistrict, the next 2-digit number denotes cluster, and an H followed by a 3-digit number denotes house number.
‡Two persons from the donor household were dengue virus–positive 2 weeks apart.‡

Main Article

1These authors contributed equally to this article.


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Page updated: May 18, 2021
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