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Volume 27, Number 7—July 2021
Research

Plasmodium falciparum kelch 13 Mutations, 9 Countries in Africa, 2014–2018

Sarah E. Schmedes1, Dhruviben Patel1, Simran Dhal, Julia Kelley, Samaly S. Svigel, Pedro Rafael Dimbu, Adicatou-Laï Adeothy, Gauthier Mesia Kahunu, Papy Mandoko Nkoli, Abdoul Habib Beavogui, Simon Kariuki, Don P. Mathanga, Ousmane Koita, Deus Ishengoma, Ally Mohamad, Moonga Hawela, Leah F. Moriarty, Aaron M. Samuels, Julie Gutman, Mateusz M. Plucinski, Venkatachalam Udhayakumar, Zhiyong Zhou, Naomi W. Lucchi, Meera Venkatesan, Eric S. Halsey, and Eldin TalundzicComments to Author 
Author affiliations: Association of Public Health Laboratories, Silver Spring, Maryland, USA (S.E. Schmedes); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.E. Schmedes, D. Patel, S.S. Svigel, A.M. Samuels, J. Gutman, M.M. Plucinski, V. Udhayakumar, Z. Zhou, N.W. Lucchi, E. Talundzic); Williams Consulting LLC, Baltimore, Maryland, USA (D. Patel); The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta (S. Dahl); CDC Foundation, Atlanta (J. Kelley); National Malaria Control Program, Ministry of Health, Luanda, Angola (P.R. Dimbu); National Malaria Control Program, Ministry of Health, Porto-Novo, Benin (A.-L. Adeothy); University of Kinshasa, Kinshasa, Democratic Republic of the Congo (G.M. Kahunu); National Institute of Biomedical Research, Kinshasa (P.M. Nkoli); Maferinyah Rural Health Research Center, Mafèrinyah, Guinea (A.H. Beavogui); Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya (S. Kariuki); University of Malawi College of Medicine, Blantyre, Malawi (D.P. Mathanga); University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali (O. Koita); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (D. Ishengoma); National Institute for Medical Research, Tanga Research Centre, Dar es Salaam, Tanzania (D. Ishengoma, A. Mohamad); Monash University Faculty of Pharmaceutical Sciences, Melbourne, Australia (D. Ishengoma); National Malaria Elimination Centre, Lusaka, Zambia (M. Hawela); US President’s Malaria Initiative, Centers for Disease Control and Prevention, Atlanta (L.F. Moriarty, M.M. Plucinski, E.S. Halsey); US President’s Malaria Initiative, US Agency for International Development, Washington, DC, USA (M. Venkatesan)

Main Article

Table 2

Summary of antimalarial therapeutic efficacy studies, 9 countries in Africa, 2002–2007*

Country Sites Treatments studied Age of patients enrolled Year Total no. samples
ACTs
introduced
D0 + DF D0 DF
Angola Benguela, Zaire, Lunda Sul AL, ASAQ, DP 6 mo–12 y 2015 379 379 0 2005




2017
76
38
38
2005
Benin
Klouanmey, Djougou
AL
6–59 mo
2017
194
175
19
2004
DRC
Kabondo, Kapolowe, Rutshuru, Mikalayi, Kimpese
AL, ASAQ, DP
6–59 mo
2017–2018
633
317
316
2006
Guinea
Maferinyah, Labè
AL
6–59 mo
2016
432
409
23
2004–2005
Kenya
Siaya County
AL, DP
6–59 mo
2016–2017
417
325
92
2006
Malawi
Machinga, Nkhotakota, Karonga
AL, ASAQ
6–59 mo
2014
27
8
19
2007
Mali
Dioro, Sèlinguè
AL, ASAQ
2–59 mo
2015–2016
410
320
90
2006
Tanzania
Kibaha, Ujiji, Mkuzi, Mlimba
AL
6 mo–10 y
2016
417
345
72
2006
Zambia
Gwembe, Katete, Mansa
AL, DP
>6 mo
2016
263
263
0
2002
Total 3,248 2,579 669

*ACTs, artemisinin-based combination therapies; AL, artemether/lumefantrine; ASAQ, artesunate/amodiaquine; D0, day of enrollment (pretreatment); DF, day of failure; DP, dihydroartemisinin/piperaquine; DRC; Democratic Republic of the Congo.

Main Article

1These authors contributed equally to this article.

Page created: April 28, 2021
Page updated: June 16, 2021
Page reviewed: June 16, 2021
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