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Volume 27, Number 7—July 2021
CME ACTIVITY - Research

Non–C. difficile Clostridioides Bacteremia in Intensive Care Patients, France

Guillaume MorelComments to Author , Guillaume Mulier, Etienne Ghrenassia, Moustafa Abdel Nabey, Yacine Tandjaoui, Achille Kouatchet, Laura Platon, Frédéric Pène, Anne-Sophie Moreau, Amelie Seguin, Damien Contou, Romain Sonneville, David Rousset, Muriel Picard, Guillaume Dumas, Djamel Mokart, Bruno Megarbane, Guillaume Voiriot, Isabelle Oddou, Elie Azoulay, Lucie Biard, and Lara Zafrani
Author affiliations: Hautepierre Hospital—University Medical Center, Strasbourg, France (G. Morel); Hospital Saint Louis, APHP, Paris, France (G. Morel, G. Mulier, E. Ghrenassia, M.A. Nabey, E. Azoulay, L. Biard, L. Zafrani); Hospital Avicenne, Bobigny, France (Y. Tandjaoui); Teaching Hospital, Angers, France (A. Kouatchet); Lapeyronie University Hospital, Montpellier, France (L. Platon); Hospital Cochin, APHP, Paris (F. Pène); Salengro Hospital, Lille, France (A.-S. Moreau); University Hospital, Nantes, France (A. Seguin); Victor Dupouy Hospital, Argenteuil, France (D. Contou); Hospital Bichat, APHP, Paris (R. Sonneville); University Teaching Hospital, Toulouse, France (D. Rousset),; Institut Universitaire du Cancer—Oncopole, Toulouse (M. Picard); Hospital Saint Antoine, APHP, Paris (G. Dumas); Paoli-Calmettes Institute, Marseille, France (D. Mokart); Hospital Lariboisiere, APHP, Paris (B. Megarbane); Hospital Tenon, APHP, Paris (G. Voiriot); University Medical Center, Strasbourg (I. Oddou); INSERM U976, Paris (L. Zafrani)

Main Article

Table 3

Characteristics of non–C. difficile bacteria in cases of Clostridioides bacteremia, France

Characteristic No. (%) patients
All patients, n = 135
 Survived, n = 65
 Died in ICU, n = 70
Clostridium species
Perfringens 42 (31) 16 (25) 26 (37)
Ramosum 18 (13) 10 (15) 8 (11)
Any Clostridioides sp. 16 (12) 6 (9) 10 (14)
Tertium 14 (10) 9 (14) 5 (7)
Clostridiforme 12 (9) 8 (12) 4 (6)
Septicum 10 (7) 2 (3) 8 (11)
Innocuum 6 (4) 5 (8) 1 (1)
Butyricum 4 (3) 2 (3) 2 (3)
Paraputrificum 3 (2) 2 (3) 1 (1)
Baratii 2 (1) 1 (2) 1 (1)
Orbiscindens 2 (1) 1 (2) 1 (1)
Sporogenes 2 (1) 1 (2) 1 (1)
Cadaveris 1 (1) 0 (0) 1 (1)
Novyi 1 (1) 1 (2) 0 (0)
Sordellii 1 (1) 0 (0) 1 (1)
Symbosium
 1 (1)
 1 (2)
 0 (0)
No. positive blood cultures for Clostridioides spp.
1 117 (87) 52 (80) 65 (93)
2 13 (10) 9 (14) 4 (6)
3
5 (4)
 4 (6)
 1 (1)
Other microbes associated with Clostridioides bacteremia, n = 49 27 22
Gram-negative bacteria 33 (67) 20 (74) 13 (59)
Gram-positive bacteria 24 (49) 12 (44) 12 (55)
Candida fungemia
 1 (2)
 1 (4)
 0 (0)
Effectiveness of tested antimicrobial drugs against Clostridioides species
Penicillin, n = 84 83 (99) 37 (100) 46 (98)
Clindamycin, n = 67 46 (69) 22 (67) 24 (71)
Vancomycin, n = 67 67 (100) 33 (100) 34 (100)
Metronidazole, n = 84
 82 (98)
 36 (97)
 46 (98)
Patients receiving drugs 110 (91) 64 (98) 46 (82)
Beta-lactams 102 (94) 60 (94) 42 (95)
Amoxicillin/clavulanic acid 9 (9) 6 (10) 3 (7)
Piperacillin/tazobactam 46 (45) 25 (42) 21 (50)
Cephalosporins 22 (22) 15 (25) 7 (17)
Carbapenems 26 (25) 15 (25) 11 (26)
Aminoglycoside 58 (54) 34 (53) 24 (55)
Anti–gram positive bacteria 46 (43) 29 (45) 17 (39)
Metronidazole 39 (36) 26 (41) 13 (30)
Others 10 (9) 5 (8) 5 (11)
Missing data
 2
 0
 2
Origin of bacteremia
Digestive origin 87 (74) 43 (70) 44 (79)
Bowel pathology 33 (28) 14 (23) 19 (34)
Mesenteric ischemia 25 (21) 7 (11) 18 (32)
Peritonitis 19 (16) 16 (26) 3 (5)
Pancreatic or biliary origin 10 (9) 6 (10) 4 (7)
Myonecrosis 19 (16) 11 (18) 8 (14)
Abscess 8 (7) 5 (8) 3 (5)
Pneumonia
 3 (3)
 2 (3)
 1 (2)
Missing data 18
 4
 14

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Page created: May 27, 2021
Page updated: June 18, 2021
Page reviewed: June 18, 2021
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