TY - JOUR AU - Morales, Maria AU - Tanabe, Melinda AU - White, A. Clinton AU - Lopez, Martha AU - Bascope, Ruben AU - Cabada, Miguel T1 - Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 7 SP - 1850 SN - 1080-6059 AB - We conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>1 doses of 10 mg/kg). Parasitologic cure was evaluated by using microscopy of stool 1–4 months after each treatment. A total of 146 children who had chronic fascioliasis participated in the study; 53% were female, and the mean ± SD age was 10.4 ± 3.1 years. After the first treatment, 55% of the children achieved parasitologic cure. Cure rates decreased after the second (38%), third (30%), and fourth (23%) treatments; 17 children (11.6%) did not achieve cure after 4 treatments. Higher baseline egg counts and lower socioeconomic status were associated with triclabendazole treatment failure. Decreased triclabendazole efficacy in disease-endemic communities threatens control efforts. Further research on triclabendazole resistance and new drugs to overcome it are urgently needed. KW - triclabendazole KW - treatment failure KW - fascioliasis KW - Fasciola hepatica KW - liver fluke KW - trematode KW - parasites KW - infection KW - efficacy KW - drug resistance KW - preschool children KW - school-age children KW - antimicrobial resistance KW - Cusco KW - Peru DO - 10.3201/eid2707.203900 UR - https://wwwnc.cdc.gov/eid/article/27/7/20-3900_article ER - End of Reference