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Volume 27, Number 8—August 2021

Plague Transmission from Corpses and Carcasses

Sophie JullienComments to Author , Nipun Lakshitha de Silva, and Paul Garner
Author affiliations: University of Barcelona, Barcelona, Spain (S. Jullien); Liverpool School of Tropical Medicine, Liverpool, UK (S. Jullien, P. Garner); General Sir John Kotelawala Defence University, Colombo, Sri Lanka (N.L. de Silva)

Main Article

Table 2

Risk for bias in studies on human-to-human transmission of plague*

Study Were patient characteristics adequately reported? Was there some effort to trace all contacts from the index case? Were the methods used for tracing contacts adequate? Were the laboratory methods used for defining a confirmed case of plague reliable? Was the route of transmission plausible? Was the cause-effect of transmission plausible?
Almeida et al. (17) Partial Unknown NA Yes No Unknown
Begier et al. (25) Yes Yes Yes Partial Yes Yes
Bertherat et al. (26) No Partial Unknown Yes Yes Yes
Evans et al. (18) Yes Unknown NA Yes Yes Yes
Kellogg et al. (20) Yes Unknown NA Yes Yes Yes
Kugeler 2015 (19) Partial Unknown NA Yes Unknown Unknown
Rabaan et al. (21) Partial Partial Unknown Yes Yes Yes
Ramasindrazana et al. (22) Yes Yes Yes Yes Yes Yes
Ratsitorahina et al. (23) Yes Yes Unknown Partial Yes Yes
Richard et al. (24) Yes Yes Unknown Yes Yes Yes

*NA, not applicable.

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  1. Rasmussen  S, Allentoft  ME, Nielsen  K, Orlando  L, Sikora  M, Sjögren  KG, et al. Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago. Cell. 2015;163:57182. DOIPubMedGoogle Scholar
  2. World Health Organization. Interregional meeting on prevention and control of plague. 2008 [cited 2019 Oct 21].
  3. World Health Organization, Regional Office for South-East Asia, Operational guidelines on plague surveillance, diagnosis, prevention and control. 2009 [cited 2019 Oct 21].
  4. Eisen  RJ, Gage  KL. Adaptive strategies of Yersinia pestis to persist during inter-epizootic and epizootic periods. Vet Res. 2009;40:114. DOIPubMedGoogle Scholar
  5. Pollitzer  R. Plague (World Health Organization Monograph Series). Geneva: World Health Organization; 1954.
  6. Centers for Disease Control and Prevention. Fatal laboratory-acquired infection with an attenuated Yersinia pestis strain—Chicago, Illinois, 2009. MMWR Morb Mortal Wkly Rep. 2011;60:2015.
  7. Weniger  BG, Warren  AJ, Forseth  V, Shipps  GW, Creelman  T, Gorton  J, et al. Human bubonic plague transmitted by a domestic cat scratch. JAMA. 1984;251:9278. DOIPubMedGoogle Scholar
  8. Wong  D, Wild  MA, Walburger  MA, Higgins  CL, Callahan  M, Czarnecki  LA, et al. Primary pneumonic plague contracted from a mountain lion carcass. Clin Infect Dis. 2009;49:e338. DOIPubMedGoogle Scholar
  9. Centers for Disease Control and Prevention. Plague. 2019 [cited 2019 Apr 15].
  10. Bramanti  B, Stenseth  NC, Walloe  L, Lei  X. Plague: a disease which changed the path of human civilization. In: Yang R, Anisimov A, editors. Yersinia pestis: retrospective and perspective. Dordrecht (Netherlands): Springer; 2016. p. 11–5.
  11. Arifuzzaman  M, Ang  WXG, Choi  HW, Nilles  ML, St John  AL, Abraham  SN. Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes. JCI Insight. 2018;3:e122188. DOIPubMedGoogle Scholar
  12. Prentice  MB, Rahalison  L. Plague. Lancet. 2007;369:1196207. DOIPubMedGoogle Scholar
  13. Center for Infectious Disease Research and Policy. Plague: agent and pathogenesis. 2013 [cited 2019 Apr 15].
  14. Poleykett  B. Ethnohistory and the dead: cultures of colonial epidemiology. Med Anthropol. 2018;37:47285. DOIPubMedGoogle Scholar
  15. Jullien  S, da Silva  NL, Garner  P. Risk of plague transmission from human cadavers. National Institute for Health Research. 2019 [cited 2019 Jan 13].
  16. Cho  MK, Bero  LA. Instruments for assessing the quality of drug studies published in the medical literature. JAMA. 1994;272:1014. DOIPubMedGoogle Scholar
  17. Almeida  CR, Almeida  AR, Vieira  JB, Guida  U, Butler  T. Plague in Brazil during two years of bacteriological and serological surveillance. Bull World Health Organ. 1981;59:5917.PubMedGoogle Scholar
  18. Evans  CM, Egan  JR, Hall  I. Pneumonic plague in Johannesburg, South Africa, 1904. Emerg Infect Dis. 2018;24:95102. DOIGoogle Scholar
  19. Kugeler  KJ, Staples  JE, Hinckley  AF, Gage  KL, Mead  PS. Epidemiology of human plague in the United States, 1900-2012. Emerg Infect Dis. 2015;21:1622. DOIPubMedGoogle Scholar
  20. Kellogg  WH. An epidemic of pneumonic plague. Am J Public Health (N Y). 1920;10:599605. DOIPubMedGoogle Scholar
  21. Rabaan  AA, Al-Ahmed  SH, Alsuliman  SA, Aldrazi  FA, Alfouzan  WA, Haque  S. The rise of pneumonic plague in Madagascar: current plague outbreak breaks usual seasonal mould. J Med Microbiol. 2019;68:292302. DOIPubMedGoogle Scholar
  22. Ramasindrazana  B, Andrianaivoarimanana  V, Rakotondramanga  JM, Birdsell  DN, Ratsitorahina  M, Rajerison  M. Pneumonic plague transmission, Moramanga, Madagascar, 2015. Emerg Infect Dis. 2017;23:5214. DOIPubMedGoogle Scholar
  23. Ratsitorahina  M, Chanteau  S, Rahalison  L, Ratsifasoamanana  L, Boisier  P. Epidemiological and diagnostic aspects of the outbreak of pneumonic plague in Madagascar. Lancet. 2000;355:1113. DOIPubMedGoogle Scholar
  24. Richard  V, Riehm  JM, Herindrainy  P, Soanandrasana  R, Ratsitoharina  M, Rakotomanana  F, et al. Pneumonic plague outbreak, Northern Madagascar, 2011. Emerg Infect Dis. 2015;21:815. DOIPubMedGoogle Scholar
  25. Begier  EM, Asiki  G, Anywaine  Z, Yockey  B, Schriefer  ME, Aleti  P, et al. Pneumonic plague cluster, Uganda, 2004. Emerg Infect Dis. 2006;12:4607. DOIPubMedGoogle Scholar
  26. Bertherat  E, Thullier  P, Shako  JC, England  K, Koné  ML, Arntzen  L, et al. Lessons learned about pneumonic plague diagnosis from two outbreaks, Democratic Republic of the Congo. Emerg Infect Dis. 2011;17:77884. DOIPubMedGoogle Scholar
  27. Ge  P, Xi  J, Ding  J, Jin  F, Zhang  H, Guo  L, et al. Primary case of human pneumonic plague occurring in a Himalayan marmot natural focus area Gansu Province, China. Int J Infect Dis. 2015;33:6770. DOIPubMedGoogle Scholar
  28. Wu  K, Wang  Y, Wang  M. Epidemiologic analysis on Tibetan sheep plague from 1975 to 2005 in Qinghai Province. Chinese Journal of Endemiology. 2009;28:6657.
  29. Zhang  H, Wang  S, Wu  D, Liang  X. Dynamic analysis of human plague epidemic situation in Gansu. Chinese Journal of Endemiology. 2007;26:824.
  30. Centers for Disease Control and Prevention. Plague—United States, 1992. MMWR Morb Mortal Wkly Rep 1992;41:787–90.
  31. Gage  KL, Dennis  DT, Orloski  KA, Ettestad  P, Brown  TL, Reynolds  PJ, et al. Cases of cat-associated human plague in the Western US, 1977-1998. Clin Infect Dis. 2000;30:893900. DOIPubMedGoogle Scholar
  32. Kartman  L. Historical and oecological observations on plague in the United States. Trop Geogr Med. 1970;22:25775.PubMedGoogle Scholar
  33. Kartman  L. The role of rabbits in sylvatic plague epidemiology, with special attention to human cases in New Mexico and use of the fluorescent antibody technique for detection of Pasteurella pestis in field specimens. Zoonoses Res. 1960;1:127.
  34. Poland  JD, Barnes  AM, Herman  JJ. Human bubonic plague from exposure to a naturally infected wild carnivore. Am J Epidemiol. 1973;97:3327. DOIPubMedGoogle Scholar
  35. von Reyn  CF, Barnes  AM, Weber  NS, Quan  T, Dean  WJ. Bubonic plague from direct exposure to a naturally infected wild coyote. Am J Trop Med Hyg. 1976;25:6269. DOIPubMedGoogle Scholar
  36. Christie  AB, Chen  TH, Elberg  SS. Plague in camels and goats: their role in human epidemics. J Infect Dis. 1980;141:7246. DOIPubMedGoogle Scholar
  37. Sagiev  Z, Meka-Mechenko  T, Kunitsa  T, Musagalieva  R, Ismailova  A, Kulbaeva  M, et al. Diseases of human plague in 1974–2003 in Kazakhstan. Ekoloji. 2019;28:3948.
  38. Mitchell  JA, Pirie  JH, Rhodes  WF, Powell  W. Epizootic among veld rodents in De Aar and neighbouring districts of the Northern Cape province. J Hyg (Lond). 1930;29:394414.PubMedGoogle Scholar
  39. Bin Saeed  AA, Al-Hamdan  NA, Fontaine  RE. Plague from eating raw camel liver. Emerg Infect Dis. 2005;11:14567. DOIPubMedGoogle Scholar
  40. Brygoo  ER, Dodin  A. [Apropos of telluric plague and burrow plague. Madagascan data] [in French]. Bull Soc Pathol Exot Filiales. 1965;58:147.PubMedGoogle Scholar
  41. Chernin  E. Richard Pearson Strong and the Manchurian epidemic of pneumonic plague, 1910-1911. J Hist Med Allied Sci. 1989;44:296319. DOIPubMedGoogle Scholar
  42. Kool  JL. Risk of person-to-person transmission of pneumonic plague. Clin Infect Dis. 2005;40:116672. DOIPubMedGoogle Scholar
  43. Didelot  X, Whittles  LK, Hall  I. Model-based analysis of an outbreak of bubonic plague in Cairo in 1801. J R Soc Interface. 2017;14:20170160. DOIPubMedGoogle Scholar
  44. Whittles  LK, Didelot  X. Epidemiological analysis of the Eyam plague outbreak of 1665-1666. Proc Biol Sci. 2016;283:20160618. DOIPubMedGoogle Scholar
  45. Teh  WL, Han  CW, Pollitzer  R. Plague in Manchuria: I. observations made during and after the second Manchurian plague epidemic of 1920–21, II. The rôle of the tarabagan in the epidemiology of plague. J Hyg (Lond). 1923;21:30758. DOIPubMedGoogle Scholar
  46. Strong  R, Teague  O. Studies on pneumonic plague and plague immunisation. II the method of transmission of the infection in pneumonic plague and manner of spread of the disease during the epidemic. The Philippine Journal of Tropical Medicine. 1912;7:13756.

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