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Volume 27, Number 8—August 2021

Comparison of Lyme Disease in the United States and Europe

Adriana R. MarquesComments to Author , Franc Strle, and Gary P. Wormser
Author affiliations: National Institutes of Health, Bethesda, Maryland, USA (A.R. Marques); University Medical Centre Ljubljana, Ljubljana, Slovenia (F. Strle); New York Medical College, Valhalla, New York, USA (G.P. Wormser)

Main Article

Table 3

Lyme disease clinical manifestations in the United States and Europe

Manifestation United States Europe
Radicular pain from Lyme neuroborreliosis
Less common in the United States*
More common in Europe
Lyme arthritis
More common in the United States in untreated patients with erythema migrans; may have septic arthritis-like presentation in children
Occurs in Europe; more commonly associated with Borrelia burgdorferi sensu stricto; septic arthritis-like manifestation in children seems to be rare
Acrodermatitis chronica atrophicans
No autochthonous US cases
Occurs in Europe (late manifestation)
Borrelial lymphocytoma
No autochthonous US cases
Occurs in Europe
Lyme encephalopathy
Controversial in the United States
Not recognized to occur
Diffuse axonal peripheral neuropathy Controversial in the United States Occurs but only in conjunction with acrodermatitis chronica atrophicans

*More studies, however, are needed.

Main Article

Page created: June 21, 2021
Page updated: July 18, 2021
Page reviewed: July 18, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.