TY - JOUR AU - Bosco-Lauth, Angela AU - Root, J. Jeffrey AU - Porter, Stephanie AU - Walker, Audrey AU - Guilbert, Lauren AU - Hawvermale, Daphne AU - Pepper, Aimee AU - Maison, Rachel AU - Hartwig, Airn AU - Gordy, Paul AU - Bielefeldt-Ohmann, Helle AU - Bowen, Richard T1 - Peridomestic Mammal Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 8 SP - 2073 SN - 1080-6059 AB - Wild animals have been implicated as the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but it is largely unknown how the virus affects most wildlife species and if wildlife could ultimately serve as a reservoir for maintaining the virus outside the human population. We show that several common peridomestic species, including deer mice, bushy-tailed woodrats, and striped skunks, are susceptible to infection and can shed the virus in respiratory secretions. In contrast, we demonstrate that cottontail rabbits, fox squirrels, Wyoming ground squirrels, black-tailed prairie dogs, house mice, and racoons are not susceptible to SARS-CoV-2 infection. Our results expand the knowledge base of susceptible species and provide evidence that human–wildlife interactions could result in continued transmission of SARS-CoV-2. KW - severe acute respiratory syndrome coronavirus 2 KW - SARS-CoV-2 KW - coronavirus KW - viruses KW - coronavirus disease KW - COVID-19 KW - respiratory infections KW - infections KW - cottontail rabbit KW - deer mouse KW - experimental infection KW - woodrat KW - squirrel KW - house mouse KW - peridomestic KW - mesocarnivore KW - raccoon KW - rodent KW - striped skunk KW - wildlife KW - zoonoses KW - United States DO - 10.3201/eid2708.210180 UR - https://wwwnc.cdc.gov/eid/article/27/8/21-0180_article ER - End of Reference