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Volume 27, Number 8—August 2021

Autochthonous Cases of Tick-Borne Encephalitis, Belgium, 2020

Anke Stoefs, Leo Heyndrickx, Jonathan De Winter, Evelien Coeckelbergh, Barbara Willekens, Alicia Alonso-Jiménez, Anne-Marie Tuttino, Yvette Geerts, Kevin K. Ariën, and Marjan Van EsbroeckComments to Author 
Author affiliations: Institute of Tropical Medicine, Antwerp, Belgium (A. Stoefs, L. Heyndrickx, K.K. Ariën, M. Van Esbroeck); University Hospital of Antwerp, Antwerp (J. De Winter, E. Coeckelbergh, B. Willekens, A. Alonso-Jiménez); University of Antwerp, Antwerp (B. Willekens, A. Alonso-Jiménez, K.K. Ariën); Vivasso, Villers-Le-Bouillet, Belgium (A.-M. Tuttino); AZ Zeno Hospital, Knokke-Heist, Belgium (Y. Geerts)

Main Article


Laboratory results confirming TBEV infections in 3 autochthonous human cases, Belgium, 2020

Case no. Symptom onset date Exposure
Sample type, days after symptom onset Flavivirus IFA
PRNT90 titer rRT-PCR
Likely site, postal code Likely route, time IgM† IgG‡
1 Jun 5 Oostkamp, 8020 Tick bite, 2 wk before symptom onset
Serum, 5 TBEV+ TBEV+ 1:25 ND

CSF, 6
2 Jun 21 Lille, 2275 Tick bite, 2 wk before symptom onset

Serum, 20
3 Jul 20 Wanze, 4520 Multiple tick bites in the weeks before symptom onset Serum, 2 ND +
Serum, 18 TBEV+ TBEV+ 1:194 ND

*CSF, cerebrospinal fluid; IFA, immunofluorescence assay; ND, not done; PRNT90, plaque reduction neutralization testing at 90% sensitivity; rRT-PCR, real-time reverse transcription PCR; TBEV, tick-borne encephalitis virus; +, positive; –, negative. †Only TBEV-positive on the flavivirus mosaic IFA. ‡Also positive signal for >1 other flavivirus on the mosaic IFA, including West Nile virus, Japanese encephalitis virus, yellow fever virus, and dengue virus serotypes 1–4.

Main Article

Page created: June 09, 2021
Page updated: July 18, 2021
Page reviewed: July 18, 2021
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