TY - JOUR AU - Lynch, Maureen AU - Macori, Guerrino AU - Fanning, Séamus AU - O’Regan, Edel AU - Hunt, Eoin AU - O’Callaghan, Dermot AU - McCullagh, Brian AU - Jennings, Cormac AU - Fortune, Anne T1 - Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 9 SP - 2499 SN - 1080-6059 AB - We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants. KW - 2019 novel coronavirus disease KW - coronavirus disease KW - COVID-19 KW - severe acute respiratory syndrome coronavirus 2 KW - SARS-CoV-2 KW - viruses KW - respiratory infections KW - zoonoses KW - immunocompromised KW - virus evolution KW - B-cell therapy KW - superinfection DO - 10.3201/eid2709.211159 UR - https://wwwnc.cdc.gov/eid/article/27/9/21-1159_article ER - End of Reference