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Volume 28, Number 1—January 2022
Research

Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe

Germaine HanquetComments to Author , Pavla Krizova, Tina Dalby, Shamez N. Ladhani, J. Pekka Nuorti, Kostas Danis, Jolita Mereckiene, Mirjam J. Knol, Brita A. Winje, Pilar Ciruela, Sara de Miguel, Maria Eugenia Portillo, Laura MacDonald, Eva Morfeldt, Jana Kozakova, Palle Valentiner-Branth, Norman K. Fry, Hanna Rinta-Kokko, Emmanuelle Varon, Mary Corcoran, Arie van der Ende, Didrik F. Vestrheim, Carmen Munoz-Almagro, Juan-Carlos Sanz, Jesus Castilla, Andrew Smith, Birgitta Henriques-Normark, Edoardo Colzani, Lucia Pastore-Celentano, Camelia Savulescu, and the SpIDnet group1
Author affiliations: Epiconcept, Paris, France (G. Hanquet, C. Savulescu); Antwerp University, Antwerp, Belgium (G. Hanquet); National Institute of Public Health, Prague, Czech Republic (P. Krizova, J. Kozakova); Statens Serum Institut, Copenhagen, Denmark (T. Dalby, P. Valentiner-Branth); Public Health England, London, UK (S.N. Ladhani, N.K. Fry); Tampere University, Tampere, Finland (J.P. Nuorti); Finnish Institute for Health and Welfare, Helsinki, Finland (J.P. Nuorti, H. Rinta-Kokko); Santé Publique France, the National Public Health Agency, Saint-Maurice, France (K. Danis); Health Protection Surveillance Centre, Dublin, Ireland, UK (J. Mereckiene); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (M.J. Knol); Norwegian Institute of Public Health, Oslo, Norway (B.A. Winje, D.F. Vestrheim); Public Health Agency of Catalonia, Barcelona, Spain (P. Ciruela); CIBER Epidemiología y Salud Pública, Madrid, Spain (P. Ciruela, C. Munoz-Almagro, J. Castilla); General Directorate of Public Health–Madrid Region, Madrid (S. de Miguel, J.-C. Sanz); Navarra Hospital Complex–IdiSNA, Pamplona, Spain (M.E. Portillo); Public Health Scotland, Glasgow, Scotland, UK (L. MacDonald); Public Health Agency of Sweden, Stockholm, Sweden (E. Morfeldt); Centre de Recherche Clinique et Biologique, Creteil, France (E. Varon); Children’s Health Ireland (CHI) at Temple Street, Dublin (M. Corcoran); Academic Medical Center, Amsterdam, the Netherlands (A. van der Ende); Hospital Sant Joan de Déu, Barcelona (C. Munoz-Almagro); Universitat Internacional of Catalunya, Barcelona (C. Munoz-Almagro); Public Health Institute of Navarra–IdiSNA, Pamplona (J. Castilla); University of Glasgow, Glasgow, Scotland, UK (A. Smith); Karolinska Institutet, Stockholm (B. Henriques-Normark); K; arolinska University Hospital, Solna, Sweden (B. Henriques-Normark); European Centre for Disease Prevention and Control, Stockholm (E. Colzani, L. Pastore-Celentano)

Main Article

Table 3

Population size by age group and site in 2018 and IPD incidence rates per PCV10/PCV13 year during 2011–2018 by age group and site, SpIDnet multicenter study, Europe*

Sites
Population, 2018
Annual incidence rate
2011
2012
2013
2014
2015
2016
2017
2018
In children <5 y
CZ 567,172 4.2 2.6 5.1 4.7 4.0 2.4 2.9 4.6
DK 300,798 10.1 11.6 11.2 11.7 7.5 8.1 9.6 5.7
EN 3,515,430 9.5 6.6 7.1 7.7 8.6 8.5 7.8 8.2
FI 267,686 23.8 10.5 10.9 9.0 7.8 11.5 10.8 12.8
FR 2,655,339 13.5 10.7 8.4 7.1 9.4 9.5 9.2 10.0
IE 319,296 11.5 11.8 10.7 10.2 9.7 11.8 12.6 15.0
NL 217,025 7.8 4.8 3.1 7.1 6.8 5.0 7.3 7.4
NO 294,863 9.1 6.1 8.3 6.1 6.2 8.5 4.6 6.8
SC 276,862 12.1 11.5 12.2 8.9 16.1 14.8 14.9 15.2
SE 604,498 7.1 4.7 5.7 5.8 3.9 5.7 4.7 6.8
CAT 359,195 41.7 38.0 25.2 24.5 30.3 26.4 25.7 28.4
MAD 320,026 23.3 16.6 16.1 15.8 18.7 17.2 18.7 17.6
NAV 30,958 20.1 14.3 28.7 33.7 42.6 24.9 28.6 29.1
All
9,729,148
12.6
9.7
8.9
8.5
9.7
9.6
9.2
9.9
In persons 5–64 y
CZ 7,996,011 2.9 2.3 2.7 2.0 2.6 1.8 2.4 2.5
DK 4,364,329 9.7 8.6 9.1 5.9 6.5 6.3 6.5 6.1
EN 44,769,133 5.1 4.6 4.2 4.2 5.3 5.8 5.6 5.5
FI 4,045,396 9.9 9.2 9.1 7.9 9.0 9.1 8.7 8.3
FR 35,961,594 6.1 5.0 4.3 3.6 3.7 3.9 4.0 4.2
IE 3,864,357 4.0 3.5 3.7 3.9 3.9 4.1 4.4 5.1
NL 3,268,467 8.6 8.2 8.2 6.7 7.7 7.0 7.1 7.5
NO 4,114,508 8.2 7.2 7.3 6.5 4.8 4.8 5.3 5.2
SC 4,135,124 6.0 5.1 6.4 4.6 6.7 8.0 7.3 6.8
SE 7,589,976 8.3 7.9 6.9 5.6 6.8 6.1 6.4 6.8
CAT 5,767,319 7.3 7.5 6.7 5.9 6.4 6.0 7.1 7.2
MAD 5,066,849 4.3 3.5 3.3 3.8 4.4 4.2 5.1 5.5
NAV 489,838 4.5 5.3 3.3 5.6 7.4 4.7 4.8 5.5
All
131,432,901
6.0
5.3
4.9
4.4
5.0
5.1
5.2
5.3
In persons >65 y
CZ 2,086,617 8.0 8.2 10.2 8.3 9.9 8.3 11.7 12.5
DK 1,116,063 57.8 56.2 47.5 45.0 51.1 44.0 44.7 49.7
EN 10,831,246 23.0 22.4 21.4 21.4 26.3 29.6 30.1 29.3
FI 1,192,077 30.3 33.6 30.2 32.5 38.0 36.1 37.2 32.9
FR 9,813,812 29.2 26.5 22.0 18.4 19.8 21.7 22.2 20.9
IE 673,362 30.1 32.2 30.1 28.6 31.2 30.1 31.9 39.4
NL 809,073 51.5 53.0 53.4 42.9 53.5 50.7 46.7 52.9
NO 897,368 51.3 42.6 38.8 38.3 37.4 44.1 37.8 38.0
SC 1,026,114 24.4 25.7 30.1 22.8 31.8 34.0 37.0 28.8
SE 2,035,711 41.6 45.5 42.1 38.8 41.1 43.7 42.6 41.7
CAT 1,417,311 27.2 32.1 34.5 29.0 33.0 31.0 34.4 37.5
MAD 1,154,255 18.9 19.1 17.9 22.6 23.5 24.5 26.6 23.9
NAV 126,482 29.2 29.5 22.2 20.6 24.7 28.5 36.1 25.3
All 33,179,491 28.3 27.7 25.6 23.6 27.0 28.5 29.1 28.5

*CAT, Catalonia; CZ, Czech Republic; DK, Denmark; EN, England; FI, Finland; FR, France; IE, Ireland; IPD, invasive pneumococcal disease; MAD, Madrid; NAV, Navarra; NL, the Netherlands; NOR, Norway; PCV, pneumococcal conjugate vaccine; SC, Scotland; SE, Sweden; SpIDnet, Streptococcus pneumoniae Invasive Disease network.

Main Article

1Members of the SpIDnet group who contributed are listed at the end of this article.

Page created: November 15, 2021
Page updated: December 20, 2021
Page reviewed: December 20, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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