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Volume 28, Number 1—January 2022
Dispatch

Extensive Dermatophytosis Caused by Terbinafine-Resistant Trichophyton indotineae, France

Arnaud Jabet1, Sophie Brun1, Anne-Cecile Normand, Sebastien Imbert, Mohammad Akhoundi, Eric Dannaoui, Laeticia Audiffred, Francois Chasset, Arezki Izri, Liliane Laroche, Renaud Piarroux, Claude Bachmeyer, Christophe Hennequin, and Alicia Moreno Sabater
Author affiliations: Assistance Publique-Hôpitaux de Paris, Paris, France (A. Jabet, S. Brun, A.-C. Normand, M. Akhoundi, E. Dannaoui, L. Audiffred, F. Chasset, A. Izri, L. Laroche, R. Piarroux, C. Bachmeyer, C. Hennequin, A. Moreno Sabater); Université Sorbonne Paris Nord, Bobigny, France (S. Brun); Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (S. Imbert); Université de Bordeaux, Pessac, France (S. Imbert); Université de Paris, Paris (E. Dannaoui); Sorbonne Université, Paris (F. Chasset, R. Piarroux, C. Hennequin, A. Moreno Sabater); Aix-Marseille Université Unité des virus émergents, Marseille, France (A. Izri).

Main Article

Figure 2

Trichophyton indotineae susceptibility to terbinafine reported from 4 countries. A) Relationships between terbinafine MIC and codon changes reported in isolates from different countries. Grey line shows terbinafine susceptibility threshold of 0.2 μg/mL. Available MICs were determined using the Clinical Laboratory and Standards Institute (https://clsi.org) or EUCAST (https://eucast.org) methods. Data show mean values. B) Prevalence of substitution points in the gene encoding SQLE. Sources shown in the Appendix. SQLE, squalene epoxidase enzyme.

Figure 2. Trichophyton indotineae susceptibility to terbinafine reported from 4 countries. A) Relationships between terbinafine MIC and codon changes reported in isolates from different countries. Grey line shows terbinafine susceptibility threshold of 0.2 μg/mL. Available MICs were determined using the Clinical Laboratory and Standards Institute (https://clsi.org) or EUCAST (https://eucast.org) methods. Data show mean values. B) Prevalence of substitution points in the gene encoding SQLE. Sources shown in the Appendix. SQLE, squalene epoxidase enzyme.

Main Article

1These first authors contributed equally to this article.

Page created: November 29, 2021
Page updated: December 20, 2021
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