TY - JOUR AU - Müller, Annelies AU - Kleynhans, Jackie AU - de Gouveia, Linda AU - Meiring, Susan AU - Cohen, Cheryl AU - Hathaway, Lucy Jane AU - von Gottberg, Anne T1 - Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012–2018 T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 1 SP - 166 SN - 1080-6059 AB - The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012–2018 (vaccine era), using multivariable logistic regression by manual backward elimination. The most common serotypes causing IPD were 8 and 19A. In patients <15 years of age, serotypes associated with increased CFR in IPD, compared with serotype 8 and controlling for confounding factors, were 11A, 13, 19F, 15A, and 6A. None of these serotypes were associated with increased CFR in meningitis. Among IPD patients >15 years of age, serotype 15B/C was associated with increased CFR. Among meningitis patients of all ages, serotype 1 was associated with increased CFR. PCV13 serotypes 1, 3, 6A, 19A, and 19F should be monitored, and serotypes 8, 12F, 15A, and 15B/C should be considered for inclusion in vaccines to reduce deaths caused by S. pneumoniae. KW - Streptococcus pneumoniae KW - streptococci KW - Streptococcus KW - bacteria KW - meningitis/encephalitis KW - serotype KW - mortality KW - polysaccharide capsule KW - South Africa KW - case-fatality ratio KW - Switzerland DO - 10.3201/eid2801.210956 UR - https://wwwnc.cdc.gov/eid/article/28/1/21-0956_article ER - End of Reference