Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 28, Number 1—January 2022
CME ACTIVITY - Synopsis

Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Charlotte Kaeuffer, Mathieu Baldacini, Tiffany Ruge, Yvon Ruch, Yves-Jean Zhu, Manon De Cian, Guillaume Philouze, Philippe Bachellier, Julie Denis, Nicolas Lefebvre, Francis Schneider, Yves Hansmann, Valérie Letscher-Bru, Raoul Herbrecht, Marcela Sabou, and François DanionComments to Author 
Author affiliations: Hôpitaux Universitaires de Strasbourg, Strasbourg, France (C. Kaeuffer, M. Baldacini, T. Ruge, Y. Ruch, Y.-J. Zhu, M. De Cian, G. Philouze, P. Bachellier, J. Denis, N. Lefebvre, F. Schneider, Y. Hansmann, V. Letscher-Bru, R. Herbrecht, M. Sabou, F. Danion); Institut de Cancérologie Strasbourg Europe, Strasbourg (R. Herbrecht); INSERM UMR-S1109, Strasbourg (F. Danion)

Main Article

Table 2

Mycologic characteristics of Kazachstania spp. infections and colonizations, Strasbourg, France, 2007–2020*

Patient
 Sample
 Fungus species
 Identification technique
 Antifungal susceptibility, μg/mL
 GenBank accession no.
Method
 FLC
 VRC
 5FC
 AMB
 CAS
1 2 blood cultures,
urine		 K. bovina
+ Candida albicans		 Sequencing Etest 24 0.125 0.012 0.047 0.25 MZ435268
EUCAST
 2
 <0.016
 <0.125
 0.015
 0.015
2
 Mediastinal collection; false membranes; pleural fluid†
 K. bovina
+ C. albicans,
+ C. glabrata
 Sequencing
 Etest
 8
 0.125
 NA
 0.5
 0.19
 MZ435270
3
 Bile (surgical sample)
 K. telluris SC
+C. albicans
 MALDI-TOF
 Etest
 >256
 0.19
 NA
 0.047
 0.25
 Not stored
4
 Esophageal biopsy;
fibroscopy: white plaques of the mucosa‡
K. bovina
+ C. albicans
 Sequencing
 Etest
 6
 0.032
 NA
 0.125
 0.25
 MZ435269
5
 Gastric liquid
 K. telluris SC
+ C. albicans
 MALDI-TOF
NA
 NA
 NA
 NA
 NA
 Not stored
6
 BAL fluid
 K. telluris SC
 MALDI-TOF
NA
 NA
 NA
 NA
 NA
 Not stored
7
 Stool
 K. telluris SC
+ C. lusitaniae
 MALDI-TOF
NA
 NA
 NA
 NA
 NA
 Not stored
8
 BAL fluid
 K. telluris SC
 MALDI-TOF
NA
 NA
 NA
 NA
 NA
 Not stored
9
 Urine, stool
 K. telluris SC
+ C. albicans
 MALDI-TOF
NA
 NA
 NA
 NA
 NA
 Not stored
10
 BAL fluid
 K. telluris SC
+ C. albicans
 MALDI-TOF
NA
 NA
 NA
 NA
 NA
 Not stored
11
 Sputum
 K. telluris SC
+ C. albicans
C. dubliniensis
A. niger
 MALDI-TOF
 AMB-fungus
 4
 0.25
 <4
 <0.5
 NA
 Not stored
12
 Stool
 K. telluris SC
+ C. albicans
 MALDI-TOF
NA
 NA
 NA
 NA
 NA
 Not stored
13 BAL fluid, stool K. telluris
+ C. kefyr		 MALDI-TOF AMB-fungus 8 0.125 <4 <0.5 NA Not stored

*AMB, amphotericin B; AMB; BAL, bronchoalveolar lavage; CAS, caspofungin; Etest (bioMérieux, https://www.biomerieux.fr); EUCAST, European Committee on Antimicrobial Susceptibility Testing; 5FC, flucytosine; FLC, fluconazole; ITC, itraconazole; MALDI-TOF, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; NA, not applicable; SC, species complex; VRC, voriconazole . †Anatomopathologic examination of the gastric perforation showed necrosis and inflammation. ‡Anatomopathologic examination of the esophageal biopsy showed no signs of invasion, leading to the diagnosis of mucocutaneous fungal infection.

Main Article

Page created: November 10, 2021
Page updated: December 17, 2021
Page reviewed: December 17, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external