Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 28, Number 11—November 2022
Research Letter

SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice

Mariana Baz, Nikita Deshpande, Charlie Mackenzie-Kludas, Francesca Mordant, Danielle Anderson, and Kanta SubbaraoComments to Author 
Author affiliations: World Health Organization Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia (M. Baz, N. Deshpande, K. Subbarao); University of Melbourne Peter Doherty Institute for Infection and Immunity, Melbourne (C. Mackenzie-Kludas, F. Mordant, D. Anderson, K. Subbarao); Victorian Infectious Diseases Reference Laboratory, Melbourne (D. Anderson)

Main Article

Table

Homologous and heterologous serum neutralizing antibody titers on days 27 and 56 after primary and secondary SARS-CoV-2 infection in hACE2K18 transgenic mice*

Primary infection, 102 TCID50 Secondary infection, 104 TCID50 Serum neutralizing antibodies (GMT) against indicated virus after primary and secondary infection
BA.1 BA.2† BA.5† Ancestral Delta
BA.1 BA.1 83/62 10/10 10/10 7‡/7‡ 7‡/8‡
Ancestral BA.1 34‡/27‡ 10/10 10/10 709/1,338 90‡/>440‡
Delta BA.1 16/60 10/35 10/53 55‡/124‡ 129/>453

*Bold indicates homologous titers. GMT, geometric mean titer; TCID50, 50% tissue culture infectious dose. †Lower limit of detection in indicated assays is 10. In other assays, the lower limit of detection is 5. ‡Serum samples from different sets of 5 mice from the group were tested on days 27 and 56.

Main Article

Page created: September 09, 2022
Page updated: October 24, 2022
Page reviewed: October 24, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external