Orthopoxvirus Seroprevalence and Infection Susceptibility in France, Bolivia, Laos, and Mali
, Nathanaël Lapidus, Abdennour Amroun, Alessandra Falchi, Chanthala Souksakhone, Mayfong Mayxay, Audrey Dubot-Pérès, Paola Mariela Saba Villarroel, Issa Diarra, Ousmane Koita, Pierre Gallian, and Xavier de Lamballerie
Author affiliations: Aix-Marseille Université-IRD 190-Inserm 1207, Marseille, France (L. Luciani, A. Amroun, A. Dubot-Pérès, P.M. Saba Villarroel, I. Diarra, P. Gallian, X. de Lamballerie); Sorbonne Université, Inserm, Saint-Antoine Hospital, Paris, France (N. Lapidus); Université de Corse Pascal Paoli, Corte, France (A. Falchi); Lao Red Cross, Vientiane, Laos (C. Souksakhone); Ministry of Health, Vientiane (M. Mayxay); University of Health Sciences, Vientiane (M. Mayxay); Mahosot Hospital, Vientiane (M. Mayxay, A. Dubot Pérès); University of Oxford, Oxford, UK (M. Mayxay, A. Dubot Pérès); University of Sciences, Bamako, Mali (I. Diarra, O. Koita); Établissement Français du Sang, La Plaine Saint Denis, France (P. Gallian)
Figure. Antibody titers and percentage of population positive for antibodies against orthopoxviruses in France in study of seroprevalence and infection susceptibility in France, Bolivia, Laos, and Mali. Serum samples from 4,448 persons were tested for antibodies against both vaccinia and cowpox virus and an orthopoxvirus neutralization titer (ONT) was determined. A, B) Overall comparison of ONT geometric mean ±SD (A) and percentage of positive participants (ONT>20) (B) according to decade of birth (p values are described in Appendix Table 1). C, D) Comparisons of ONT geometric mean ±SD (C) and percentage of positive persons (ONT>20) (D) between male and female participants according to decade of birth. E, F) Comparisons of ONT geometric mean ±SD (E) and percentage of positive persons (ONT>20) (F) for populations in 4 different regions of France according to their decade of birth (p values are described in Appendix Table 2). Mann-Whitney tests were used to determine geometric means ±SD; Fisher exact tests were used to compare percentage of positive persons. A p value <0.05 was considered significant.
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