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Volume 28, Number 12—December 2022

Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France

Nadim CassirComments to Author , Florian Cardona, Hervé Tissot-Dupont, Christiane Bruel, Barbara Doudier, Salima Lahouel, Karim Bendamardji, Céline Boschi, Sarah Aherfi, Sophie Edouard, Jean-Christophe Lagier, Philippe Colson, Philippe Gautret, Pierre-Edouard Fournier, Philippe Parola, Philippe Brouqui, Bernard La-Scola, and Matthieu Million
Author affiliations: IHU-Méditerranée Infection, Marseille, France (N. Cassir, F. Cardona, H. Tissot-Dupont, B. Doudier, S. Lahouel, K. Bendamardji, C. Boschi, S. Aherfi, S. Edouard, J.-C. Lagier, P. Colson, P. Gautret, P.-E. Fournier, P. Parola, P. Brouqui, B. La-Scola, M. Million); Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille (N. Cassir, H. Tissot-Dupont, C. Boschi, S. Aherfi, S. Edouard, J.-C. Lagier, P. Colson, P. Gautret, P. Brouqui, B. La-Scola, M. Million); Assistance Publique Hôpitaux de Marseille, Marseille (F. Cardona, B. Doudier, S. Lahouel, K. Bendamardji); Regional Health Agency of Provence-Alpes-Côte d'Azur (ARS Paca), Marseille (C. Bruel); Aix Marseille Université, IRD, AP-HM, SSA, VITROME, Marseille (P.-E. Fournier, P. Parola)

Main Article

Table 2

Clinical characteristics of symptomatic patients with monkeypox in Marseille during the 2022 outbreak in southern France*

Variable No. (%) patients
Systemic features
>1 systemic feature 98 (73)
Systemic symptoms before rash onset 90 (69.8)
Fever 72 (55.8)
Influenza-like illness 44 (35.1)
Sore throat
11 (8.5)
Clinical features of rash
Approximate number of lesions
>50 0
11–50 17 (13.2)
1–10 98 (73)
Type of lesion
Papular 26 (21)
Vesicular 60 (49)
Pustular 25 (20)
Scabbed 10 (7.8)
Asynchronous rash
41 (30.1)
Lesion location
Genital 68 (52.7)
Perianal 63 (48.8)
Oral ulcer 3 (2.3)
Perioral 22 (17.1)
Hands and feet 13 (10.1)
28 (21.7)
Any lymphadenopathy 51 (39.5)
Regional at site of lesion 47 (36.4)
Cervical 26 (20.2)
Inguinal 28 (21.7)
4 (3.1)
Any complication 34 (26.4)
Complication by type
Proctitis 30 (23.3)
Tonsillitis 5 (3.9)
Penile edema 5 (3.9)
Bacterial skin abscess 4 (3.1%)
Exanthem 3 (2.3%)

*Total number of patients evaluated was 129.

Main Article

Page created: October 04, 2022
Page updated: November 21, 2022
Page reviewed: November 21, 2022
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