Volume 28, Number 2—February 2022
Dispatch
SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia
Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K. Taubenberger, Matthew J. Memoli, Kaitlyn Sadtler, Patrick E. Duffy, and Fabiano Oliveira
Table
SARS-CoV-2 ELISA results by cutoff values in prepandemic serum samples from rural malaria-experienced persons in 3 Cambodia provinces, 2005–2011*
| Province | Year | Total | No. positive by 2 SDs | No. positive by 3 SDs | No. positive, Mali |
|---|---|---|---|---|---|
| Preah Vihear |
2011 |
81 |
12 (15) |
6 (7) |
5 (6) |
| Pursat | 2005 | 80 | 8 (10) | 4 (5) | 3 (4) |
| 2009 | 76 | 12 (16) | 6 (8) | 3 (0.9) | |
| 2010 | 81 | 5 (6) | 3 (4) | 1 (0.3) | |
| 2011 | 110 | 17 (15.5) | 12 (11) | 6 (5.4) | |
| Subtotal |
347 |
42 (12) |
25 (7) |
13 (3.7) |
|
| Ratanakiri |
2011 |
100 |
19 (19) |
6 (6) |
5 (5) |
| Total | All | 528 | 73 (13.8) | 37 (7) | 23 (4.4) |
*Values are no. (%) except as indicated. Using United States arbitrary ELISA unit cutoffs of 2 SDs for spike (0.674) and receptor binding domain (RBD) (0.306); United States 3 SDs for spike (0.910) and RBD (0.387); and Mali cutoff for spike (0.791) and RBD (1.183). SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
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