TY - JOUR AU - Piret, Jocelyne AU - Boivin, Guy T1 - Viral Interference between Respiratory Viruses T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 2 SP - 273 SN - 1080-6059 AB - Multiple respiratory viruses can concurrently or sequentially infect the respiratory tract and lead to virus‒virus interactions. Infection by a first virus could enhance or reduce infection and replication of a second virus, resulting in positive (additive or synergistic) or negative (antagonistic) interaction. The concept of viral interference has been demonstrated at the cellular, host, and population levels. The mechanisms involved in viral interference have been evaluated in differentiated airway epithelial cells and in animal models susceptible to the respiratory viruses of interest. A likely mechanism is the interferon response that could confer a temporary nonspecific immunity to the host. During the coronavirus disease pandemic, nonpharmacologic interventions have prevented the circulation of most respiratory viruses. Once the sanitary restrictions are lifted, circulation of seasonal respiratory viruses is expected to resume and will offer the opportunity to study their interactions, notably with severe acute respiratory syndrome coronavirus 2. KW - viral interference KW - viruses KW - respiratory viruses KW - respiratory infections KW - influenza virus KW - respiratory syncytial virus KW - human rhinovirus KW - human metapneumovirus KW - severe acute respiratory syndrome coronavirus 2 KW - SARS-CoV-2 KW - coronavirus disease KW - COVID-19 KW - zoonoses KW - innate immunity KW - interferon DO - 10.3201/eid2802.211727 UR - https://wwwnc.cdc.gov/eid/article/28/2/21-1727_article ER - End of Reference