Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures
Dustin W. Currie
, Melisa M. Shah, Phillip P. Salvatore, Laura Ford, Melissa J. Whaley, Jennifer Meece, Lynn Ivacic, Natalie J. Thornburg, Azaibi Tamin, Jennifer L. Harcourt, Jennifer Folster, Magdalena Medrzycki, Shilpi Jain, Phili Wong, Kimberly Goffard, Douglas Gieryn, Juliana Kahrs, Kimberly Langolf, Tara Zochert, Christopher H. Hsu, Hannah L. Kirking, Jacqueline E. Tate, and for the CDC COVID-19 Response Epidemiology Field Studies Team1
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (D.W. Currie, M.M. Shah, P.P. Salvatore, L. Ford, M.J. Whaley, N.J. Thornburg, A. Tamin, J.L. Harcourt, J. Folster, M. Medrzycki, S. Jain, P. Wong, C.H. Hsu, H.L. Kirking, J.E. Tate); Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA (J. Meece, L. Ivacic); Winnebago County Health Department, Oshkosh, Wisconsin, USA (K. Goffard, D. Gieryn); University of Wisconsin‒Oshkosh, Oshkosh (J. Kahrs, K. Langolf, T. Zochert)
Figure. Box plots of Ct values among participants with recoverable virus who had concordant positive SARS-CoV-2 RT-PCR and antigen test results (A) compared with those who had positive RT-PCR and negative antigen test results (B), Winnebago County, Wisconsin, USA, November–December 2020. The difference between the 2 groups was significant (p<0.0001). Diamonds indicate means, boxes indicate the first quartile through the third quartile, horizontal bars in boxes indicate medians, and errors bars indicate minimum values to maximum values; outliers are plotted as individual circles. Ct, cycle threshold; RT-PCR, reverse transcription PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
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