, Sergio A. Hernández2
, Miša Korva, Petra Bogovič, Tereza Rojko, Lara Lusa, Geena Chiumento, Franc Strle3
, and Klemen Strle3
Figure 2. Heat map analysis of inflammatory mediators in CSF stratified by clinical presentation of LNB among patients with Lyme neuroborreliosis treated in Ljubljana, Slovenia, during 2006–2013. A) Levels of inflammatory mediators stratified by LNB manifestation. B) Hierarchical clustering analysis (Euclidian distance) of inflammatory mediators and CSF leukocyte counts. We assessed the levels of 17 cytokines and chemokines associated with innate and adaptive (T- and B-cell) responses in CSF of patients with meningoradiculoneuritis, PFP/meningitis, or suspected LNB. Each column represents an individual patient, with the corresponding mediators along the different rows. Heat map was constructed using Morpheus software (https://software.broadinstitute.org/morpheus). In the case of IFN-α, 3 values were exceptionally low (at lower limit of detection), resulting in disproportionately intense red coloring of other values. CSF, cerebrospinal fluid; CXCL, CXC motif chemokine ligand; GM-CSF, granulocyte macrophage colony–stimulating factor; IL, interleukin; IFN, interferon; LNB, Lyme neuroborreliosis; MIP, macrophage inflammatory protein; PFP, peripheral facial palsy; TNF, tumor necrosis factor.