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Volume 28, Number 4—April 2022
Dispatch

Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

Eric D. Laing, Carol D. Weiss, Emily C. Samuels, Si’Ana A. Coggins, Wei Wang, Richard Wang, Russell Vassell, Spencer L. Sterling, Marana S. Tso, Tonia Conner, Emilie Goguet, Matthew Moser, Belinda M. Jackson-Thompson, Luca Illinik, Julian Davies, Orlando Ortega, Edward Parmelee, Monique Hollis-Perry, Santina E. Maiolatesi, Gregory Wang, Kathleen F. Ramsey, Anatalio E. Reyes, Yolanda Alcorta, Mimi A. Wong, Alyssa R. Lindrose, Christopher A. Duplessis, David R. Tribble, Allison M.W. Malloy, Timothy H. Burgess, Simon D. Pollett, Cara H. Olsen, Christopher C. Broder, and Edward MitreComments to Author 
Author affiliations: Uniformed Services University, Bethesda, Maryland, USA (E.D. Laing, E.C. Samuels, S.A. Coggins, S.L. Sterling, M.S. Tso, T. Conner, E. Goguet, M. Moser, B.M. Jackson-Thompson, L. Illinik, J. Davies, O. Ortega, E. Parmelee, A.R. Lindrose, D.R. Tribble, A.M.W. Malloy, T.H. Burgess, S.D. Pollett, C.H. Olsen, C.C. Broder, E. Mitre); US Food and Drug Administration, Silver Spring, Maryland, USA (C.D. Weiss, W. Wang, R. Wang, R. Vassell); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda (E.C. Samuels, S.A. Coggins, S.L. Sterling, E. Goguet, M. Moser, B.M. Jackson-Thompson, L. Illinik, J. Davies, O. Ortega, E. Parmelee, S.E. Maiolatesi, A.R. Lindrose, S.D. Pollett); Naval Medical Research Center, Silver Spring (L. Illinik, J. Davies, O. Ortega, E. Parmelee, M. Hollis-Perry, S.E. Maiolatesi, G. Wang, K.F. Ramsey, A.E. Reyes, Y. Alcorta, M.A. Wong, C.A. Duplessis); General Dynamics Information Technology, Falls Church, Virginia, USA (G. Wang, K.F. Ramsey, A.E. Reyes, Y. Alcorta, M.A. Wong)

Main Article

Table

Demographic characteristics of US healthcare worker participants in the Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study, January–August 2021*

Characteristic BNT162b2 
vaccinated Vaccinated with 6-mo follow-up bAb Vaccinated with 6-mo follow-up nAb titers Unvaccinated
Total
 227 (100)
 187 (100)
 49 (100)
 17 (100)
Sex
F 159 (70) 131 (70) 33 (67) 13 (76)
M
 68 (30)
 56 (30)
 16 (33)
 4 (24)
Ethnicity
Non-Hispanic 209 (92) 175 (94) 47 (96) 16 (94)
Hispanic 14 (6) 10 (5) 1 (2) 1 (6)
Not reported
 4 (2)
 2 (1)
 1 (2)
 0
Race
White 165 (73) 139 (74) 35 (71) 9 (53)
Black 26 (11.5) 18 (9.5) 4 (8) 6 (35)
Asian 23 (10) 19 (10) 8 (16) 1 (6)
>2 races 7 (3) 6 (3) 1 (2) 1 (6)
Native Hawaiian or other Pacific Islander 1 (0.5) 1 (0.5) 1 (2) 0
Not reported
 5 (2)
 4 (2)
 0
 0
Age, y, mean (range) 41.7 (20–69) 42.8 (21–69) 44.7 (26–69) 32.3 (19–50)

*Values are no. (%) except as indicated. bAb, binding antibodies; nAb, neutralizing antibodies.

Main Article

Page created: January 25, 2022
Page updated: March 19, 2022
Page reviewed: March 19, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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