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Volume 28, Number 6—June 2022

Burkholderia pseudomallei in Environment of Adolescent Siblings with Melioidosis, Kerala, India, 2019

Praveena Bhaskaran, Vinitha Prasad, Anusha Gopinathan, Tushar Shaw, Suchitra Sivadas, Chandrasekhar Jayakumar, Soumi Chowdhury, Aparna Dravid, Chiranjay Mukhopadhyay, and Anil KumarComments to Author 
Author affiliations: Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, India (P. Bhaskaran, V. Prasad, S. Sivadas, C. Jayakumar, A. Kumar); SRM Medical College Hospital and Research Centre, Chennai, India (A. Gopinathan); Ramaiah University of Applied Sciences, Bangalore, India (T. Shaw); Manipal Academy of Higher Education, Manipal, India (T. Shaw, S. Chowdhury, A. Dravid, C. Mukhopadhyay)

Main Article


Clinical and laboratory characteristics of 2 siblings with melioidosis, Kerala, India, 2019*

Characteristic Patient 1, 15-year-old boy† Patient 2, 12-year-old boy‡
Comorbidities None None
Date of admission Jul 1 Aug 8
Clinical condition
Pneumonia, ARDS, septic shock
Fever, sore throat, cervical lymphadenopathy
Hemoglobin (ref 12.7–17.7), g/dL 13 13.4
Total leukocytes (ref 5,500–15,500), cells/μL 3,190 14,260
Neutrophils (ref 55–70), % 90 73.1
Thrombocytes (ref 150–400), K/µL 100 223
AST (ref 0–51), IU/L 139.4 21.2
ALT (ref 0–39), IU/L 98 16.3
Creatinine (ref 0.4–1.06), mg/dL 26.4/1.13 0.54
BUN (ref 5–20), mg/dl 26.4 14.3
Ferritin (ref 36–311), ng/mL 5,448 1374
Procalcitonin (refR <0.5), ng/mL 6.8 0.36
C-reactive protein (ref <10), mg/L) 319 16.86
Culture (source) Burkholderia pseudomallei (blood, skin lesions) B. pseudomallei (lymph node, throat swab)
Blood PCR
Positive for Burkholderia mallei/B. pseudomallei
Not detected
Diagnosis (manifestations)
Melioidosis (pneumonia, ARDS, sepsis)
Melioidosis (lymphadenitis)
Piperacillin/tazobactam, meropenem, vancomycin
Ceftazidime, meropenem, trimethoprim/sulfamethoxazole
Outcome Died Jul 2 Discharged Sep 20

*ARDS, acute respiratory distress syndrome; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ref, reference range.

Main Article

Page created: March 23, 2022
Page updated: May 22, 2022
Page reviewed: May 22, 2022
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