Figure 5. Extreme excess of heterozygous sites in the US hound–derived Leishmania infantum isolates. The group-specific inbreeding coefficient F is shown for all polymorphic sites in the respective parasite population. F measures the deviation of the frequency of heterozygotes from Hardy-Weinberg equilibrium with negative values indicating an excess and positive values a deficiency of heterozygotes over homozygotes. Horizontal lines within boxes indicate medians; box top and bottom lines indicate 25 and 75 percentiles; and error bars indicate minimum and maximum values, excluding outliers.