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Volume 28, Number 6—June 2022
Research Letter

Experimental Infection of Mink with SARS-COV-2 Omicron Variant and Subsequent Clinical Disease

Jenni Virtanen1Comments to Author , Kirsi Aaltonen1, Kristel Kegler, Vinaya Venkat, Thanakorn Niamsap, Lauri Kareinen, Rasmus Malmgren, Olga Kivelä, Nina Atanasova, Pamela Österlund, Teemu Smura, Antti Sukura, Tomas Strandin, Lara Dutra, Olli Vapalahti, Heli Nordgren, Ravi Kant, and Tarja Sironen
Author affiliations: University of Helsinki, Helsinki, Finland (J. Virtanen, K. Aaltonen, K. Kegler, V. Venkat, T. Niamsap, L. Kareinen, R. Malmgren, O. Kivelä, N. Atanasova, T. Smura, A. Sukura, T. Strandin, L. Dutra, O. Vapalahti, H. Nordgren, R. Kant, T. Sironen); Finnish Meteorological Institute, Helsinki (N. Atanasova); Finnish Institute for Health and Welfare, Helsinki (P. Österlund); Helsinki University Hospital, Helsinki (O. Vapalahti)

Main Article


Results of PCR and cell culture testing for SARS-CoV-2 Omicron variant in saliva samples from 3 experimentally infected mink and 2 uninfected recipient mink*

Mink ID 1 dpi 2 dpi 3 dpi 4 dpi 5 dpi 6 dpi 7 dpi 8 dpi 9 dpi 10 dpi
Infected mink
451 +/ND +/+ +/− +/− +/− +/− +/−
453 +/(+) +/− +/− +/− +/− +/− +/ND

Recipient mink
452 (+)/+ −/− +/ND +/− +/− +/+ +/− +/− +/− (+)/−
454 -/+ −/+ (+)/− +/− +/− +/ND +/ND +/− +/− +/−

*Plus sign alone indicates signal detected with both primers of Luna SARS-CoV-2 reverse transcription quantitative PCR Multiplex Assay Kit (New England BioLabs Inc., and cycle threshold value from cell culture media was >5 cycles lower than that of the original saliva sample. Plus symbol in parentheses indicates signal detected only with 1 of 2 primers and cycle threshold value from cell culture media was 1–5 cycles lower than that of the original saliva sample. Minus sign indicates no signal with either of the primers and no cytopathic effect was detected in cell culture or cycle threshold value from the culture media was the same or higher than that of the original sample. dpi, days postinfection; ID, identification; ND, not done.

Main Article

1These authors contributed equally to this article.

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Page updated: May 22, 2022
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