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Volume 28, Number 7—July 2022
Research

One Health Genomic Analysis of Extended-Spectrum β-Lactamase‒Producing Salmonella enterica, Canada, 2012‒2016

Amrita BharatComments to Author , Laura Mataseje, E. Jane Parmley, Brent P. Avery, Graham Cox, Carolee A. Carson, Rebecca J. Irwin, Anne E. Deckert, Danielle Daignault, David C. Alexander, Vanessa Allen, Sameh El Bailey, Sadjia Bekal, Greg J. German, David Haldane, Linda Hoang, Linda Chui, Jessica Minion, George Zahariadis, Richard J. Reid-Smith, and Michael R. Mulvey
Author affiliations: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A. Bharat, L. Mataseje, G. Cox, M.R. Mulvey); University of Manitoba, Winnipeg (A. Bharat, G. Cox, M.R. Mulvey); Public Health Agency of Canada, Guelph, Ontario, Canada (E.J. Parmley, B.P. Avery, C.A. Carson, R.J. Irwin, A.E. Deckert, R.J. Reid-Smith); University of Guelph, Guelph (E.J. Parmley); Public Health Agency of Canada, St. Hyacinthe, Quebec, Canada (D. Daignault); Cadham Provincial Laboratory, Winnipeg (D.C. Alexander); Public Health Ontario Laboratories, Toronto, Ontario, Canada (V. Allen); Horizon Health Network, Saint John, New Brunswick, Canada (S. El Bailey); Laboratoire de Santé Publique du Quebec, Sainte-Anne-de-Bellevue, Quebec, Canada (S. Bekal); Queen Elizabeth Hospital, Charlottetown, Prince Edward Island, Canada (G.J. German); Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (D. Haldane); British Columbia Center for Disease Control, Vancouver, British Columbia, Canada (L. Hoang); Public Health Laboratory, Edmonton, Alberta, Canada (L. Chiu); University of Alberta, Edmonton (L. Chui); Roy Romanow Provincial Laboratory, Regina, Saskatchewan, Canada (J. Minion); Newfoundland and Labrador Public Health and Microbiology Laboratory, St. John’s, Newfoundland, Canada (G. Zahariadis)

Main Article

Figure 2

Phylogenetic dendrogram of extended-spectrum β-lactamase‒producing Salmonella enterica serovars Typhimurium and 4,5,12,i:-, Canada. The maximum likelihood dendrogram was created by using the single-nucleotide variant (SNV) phylogenomics (SNVPhyl) pipeline (https://snvphyl.readthedocs.io/en/latest) based on SNVs in the core genome. The reference genome is Salmonella Typhimurium strain LT2 (GenBank accession no. NC_003197.2). The tree is based on a core genome that represents 96% of the reference genome. Numbers along branches indicate branch support values. Sample N17-03254 was a clinical isolate from a sick pig (green), and all other samples were from human sources (orange, n = 14). Extended-spectrum β-lactamase genes are indicated to the right of the 3 largest clusters. The dataset comprises 1,599 SNVs, and SH-like branch support values are displayed.

Figure 2. Phylogenetic dendrogram of extended-spectrum β-lactamase‒producing Salmonella enterica serovars Typhimurium and 4,5,12,i:-, Canada. The maximum likelihood dendrogram was created by using the single-nucleotide variant (SNV) phylogenomics (SNVPhyl) pipeline (https://snvphyl.readthedocs.io/en/latest) based on SNVs in the core genome. The reference genome is Salmonella Typhimurium strain LT2 (GenBank accession no. NC_003197.2). The tree is based on a core genome that represents 96% of the reference genome. Numbers along branches indicate branch support values. Sample N17-03254 was a clinical isolate from a sick pig (green), and all other samples were from human sources (orange, n = 14). Extended-spectrum β-lactamase genes are indicated to the right of the 3 largest clusters. The dataset comprises 1,599 SNVs, and SH-like branch support values are displayed.

Main Article

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Page updated: June 18, 2022
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