TY - JOUR AU - Bharat, Amrita AU - Mataseje, Laura AU - Parmley, E. Jane AU - Avery, Brent AU - Cox, Graham AU - Carson, Carolee AU - Irwin, Rebecca AU - Deckert, Anne AU - Daignault, Danielle AU - Alexander, David AU - Allen, Vanessa AU - El Bailey, Sameh AU - Bekal, Sadjia AU - German, Greg AU - Haldane, David AU - Hoang, Linda AU - Chui, Linda AU - Minion, Jessica AU - Zahariadis, George AU - Reid-Smith, Richard AU - Mulvey, Michael T1 - One Health Genomic Analysis of Extended-Spectrum β-Lactamase‒Producing Salmonella enterica, Canada, 2012‒2016 T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 7 SP - 1410 SN - 1080-6059 AB - Extended-spectrum β-lactamases (ESBLs) confer resistance to extended-spectrum cephalosporins, a major class of clinical antimicrobial drugs. We used genomic analysis to investigate whether domestic food animals, retail meat, and pets were reservoirs of ESBL-producing Salmonella for human infection in Canada. Of 30,303 Salmonella isolates tested during 2012–2016, we detected 95 ESBL producers. ESBL serotypes and alleles were mostly different between humans (n = 54) and animals/meat (n = 41). Two exceptions were blaSHV-2 and blaCTX-M-1 IncI1 plasmids, which were found in both sources. A subclade of S. enterica serovar Heidelberg isolates carrying the same IncI1-blaSHV-2 plasmid differed by only 1–7 single nucleotide variants. The most common ESBL producer in humans was Salmonella Infantis carrying blaCTX-M-65, which has since emerged in poultry in other countries. There were few instances of similar isolates and plasmids, suggesting that domestic animals and retail meat might have been minor reservoirs of ESBL-producing Salmonella for human infection. KW - antimicrobial resistance KW - One Health KW - genomic analysis KW - extended-spectrum β-lactamases KW - ESBL KW - Salmonella enterica KW - bacteria KW - food safety KW - food-borne infections KW - food animals KW - retail meats KW - pets KW - zoonoses KW - Canada DO - 10.3201/eid2807.211528 UR - https://wwwnc.cdc.gov/eid/article/28/7/21-1528_article ER - End of Reference