TY - JOUR AU - Desmet, Stefanie AU - Theeten, Heidi AU - Laenen, Lies AU - Cuypers, Lize AU - Maes, Piet AU - Bossuyt, Wouter AU - Van Heirstraeten, Liesbet AU - Peetermans, Willy AU - Lagrou, Katrien T1 - Characterization of Emerging Serotype 19A Pneumococcal Strains in Invasive Disease and Carriage, Belgium T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 8 SP - 1606 SN - 1080-6059 AB - After switching from 13-valent to 10-valent pneumococcal conjugate vaccine (PCV10) (2015–2016) for children in Belgium, we observed rapid reemergence of serotype 19A invasive pneumococcal disease (IPD). Whole-genome sequencing of 166 serotype 19A IPD isolates from children (n = 54) and older adults (n = 56) and carriage isolates from healthy children (n = 56) collected after the vaccine switch (2017–2018) showed 24 sequence types (STs). ST416 (global pneumococcal sequence cluster [GPSC] 4) and ST994 (GPSC146) accounted for 75.9% of IPD strains from children and 65.7% of IPD (children and older adults) and carriage isolates in the PCV10 period (2017–2018). These STs differed from predominant 19A IPD STs after introduction of PCV7 (2011) in Belgium (ST193 [GPSC11] and ST276 [GPSC10]), which indicates that prediction of emerging strains cannot be based solely on historical emerging strains. Despite their susceptible antimicrobial drug profiles, these clones spread in carriage and IPD during PCV10 use. KW - pneumococcal strains KW - bacteria KW - vaccines KW - serotypes KW - emerging serotype 19A KW - invasive disease KW - carriage KW - respiratory infections KW - vaccine-preventable diseases KW - Belgium KW - Streptococcus pneumoniae KW - antimicrobial resistance DO - 10.3201/eid2808.212440 UR - https://wwwnc.cdc.gov/eid/article/28/8/21-2440_article ER - End of Reference