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Volume 28, Number 8—August 2022
Research

Invasive Pneumococcal Disease and Long-Term Mortality Rates in Adults, Alberta, Canada

Kristen A. Versluys, Dean T. EurichComments to Author , Thomas J. Marrie, and Gregory J. Tyrrell
Author affiliations: University of Alberta, Edmonton, Alberta, Canada (K.A. Versluys, D.T. Eurich, G.T. Tyrrell); Dalhousie University, Halifax, Nova Scotia, Canada (T.J. Marrie); Provincial Laboratory for Public Health, Edmonton (G.T. Tyrrell)

Main Article

Table 1

Characteristics for case-patients and controls for invasive pneumococcal disease long-term mortality rates in adults, Alberta, Canada*

Characteristic Case-patients Controls
Total
4,522 (100.0)
8,837 (100.0)
Sex
M 2,565 (56.7) 4,994 (56.5)
F
1,957 (43.3)
3,843 (43.5)
Age, y
<45 1,324 (29.3) 2,579 (29.2)
45‒60 1,388 (30.7) 2,735 (30.9)
60‒75 1,054 (23.3) 2,060 (23.3)
>75 756 (16.7) 1,463 (16.6)
Mean age, y (+SD)
55.8 (17.7)
55.8 (17.7)
Type of IPD
Pneumonia 2,008 (44.4)
Positive blood culture 1,961 (97.7)
Positive pleural fluid 16 (0.8)
Positive pericardial fluid 3 (0.1)
Positive peritoneal fluid 2 (0.1)
Unknown 26 (1.3)
Meningitis 116 (2.6)
Bacteremia/sepsis 2,315 (51.2)
Unspecified type 646 (14.3)
Unknown
1,496 (33.0)

Median comorbidity score (IQR)
5 (2‒9)
5 (2‒8)
Comorbidities
Asplenia 25 (0.6) 22 (0.5)
Solid organ transplant 113 (2.5) 187 (4.2)
HIV infection 136 (3.0) 41 (0.9)
Other immunosuppression conditions† 1,456 (32.2) 2,252 (50.0)
Malignancies 1,052 (23.3) 1,889 (41.9)
Chronic obstructive pulmonary disease 1,193 (26.4) 1,469 (32.6)
Other respiratory diseases‡ 771 (17.1) 1,139 (25.3)
Asthma 1,045 (23.1) 1,506 (33.4)
Chronic renal disease 502 (11.1) 881 (19.6)
Hypertension 1,790 (39.6) 2,744 (60.9)
Ischemic heart disease 990 (21.9) 1,925 (42.7)
Arrhythmias 1,662 (36.8) 2,785 (61.8)
Valvular heart disease 244 (54.0) 512 (11.4)
Congestive heart failure 645 (14.3) 1,207 (26.8)
Chronic liver disease 806 (17.8) 863 (19.2)
Diabetes 1,057 (23.4) 1,768 (39.2)
Smoking 907 (20.1) 1,136 (25.2)
Harmful alcohol use§ 1,968 (43.5) 2,503 (55.6)

*Values are no. (%) except as indicated. †Neutropenia, leukopenia, leukocyte disease, functional and genetic leukocyte cell abnormalities, myelofibrosis, disorders of immune mechanism. ‡Acute bronchitis, pneumoconiosis, pneumonitis, pulmonary embolism, and other pulmonary circulation disorders. §Alcohol related disorders, toxic effects of alcohol, alcoholic polyneuropathy, alcoholic cardiomyopathy, alcoholic gastritis, alcoholic fatty liver disease, alcoholic cirrhosis, alcoholic liver disease, alcohol abuse counseling and surveillance.

Main Article

Page created: July 11, 2022
Page updated: July 20, 2022
Page reviewed: July 20, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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