Zoonotic Threat of G4 Genotype Eurasian Avian-Like Swine Influenza A(H1N1) Viruses, China, 2020
, Kaibiao Chen1
, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, and Xiufan Liu
Author affiliations: Yangzhou University, Yangzhou, China (M. Gu, K. Chen, Z. Ge, J. Jiao, T. Cai, S. Liu, X. Wang, X. Jiao, D. Peng, X. Liu); Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou (M. Gu, X. Wang, X. Jiao, D. Peng, X. Liu)
Figure 2. Pathogenicity of 2 G4 Eurasian avian-like influenza A(H1N1) swine isolates from pigs in China in BALB/c mice. A) Body weight change of infected mice. B) Survival curve of infected mice. Two groups of five 6-week-old BALB/c mice were inoculated intranasally with A/swine/Jiangsu/HD11/2020(H1N1) (HD11) or A/swine/Anhui/HD21/2020(H1N1) (HD21) at a dose of 106 50% egg infectious dose/50 µL. Another 5 mice mock-infected with phosphate-buffered saline were served as control. Body weight change and survival rate were recorded daily until 14 days postinoculation, and mice that lost ≥25% of the initial body weight were humanely euthanized.
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