Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 28, Number 8—August 2022
Research

Dominant Carbapenemase-Encoding Plasmids in Clinical Enterobacterales Isolates and Hypervirulent Klebsiella pneumoniae, Singapore

Melvin Yong, Yahua Chen, Guodong Oo, Kai Chirng Chang, Wilson H.W. Chu, Jeanette Teo, Indumathi Venkatachalam, Natascha May Thevasagayam, Prakki S. Rama Sridatta, Vanessa Koh, Andrés E. Marcoleta, Hanrong Chen, Niranjan Nagarajan, Marimuthu Kalisvar, Oon Tek Ng, and Yunn-Hwen GanComments to Author 
Author affiliations: National University of Singapore, Singapore (M. Yong, Y. Chen, G. Oo, K.C. Chang, W.H.W. Chu, N. Nagarajan, M. Kalisvar, Y.-H. Gan); National University Hospital, Singapore (J. Teo); Singapore General Hospital, Singapore (I. Venkatachalam); National Centre for Infectious Diseases, Singapore (N.M. Thevasagayam, P.S.R. Sridatta, V. Koh, M. Kalisvar, O.T. Ng); Tan Tock Seng Hospital, Singapore (V. Koh, M. Kalisvar, O.T. Ng); Universidad de Chile, Santiago, Chile (A.E. Marcelota); Genome Institute of Singapore, Singapore (H. Chen, N. Nagarajan); Nanyang Technological University, Singapore (O.T. Ng)

Main Article

Figure 1

Flowchart of steps used for identifying dominant carbapenemase-encoding plasmids in clinical Enterobacterales isolates and hypervirulent Klebsiella pneumoniae, Singapore. We collected 1,312 samples available in the CaPES collection and analyzed 1,215 whole-genome sequenced samples. We identified 2 dominant clusters with large numbers of carbapenemase-encoding plasmids; the blaKPC–dominant cluster comprised pKPC2 plasmids and the blaNDM–dominant cluster pNDM1 plasmids. CaPES, Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) (Enterobacteriaceae is the former name of Enterobacterales); WGS, whole-genome sequencing.

Figure 1. Flowchart of steps used for identifying dominant carbapenemase-encoding plasmids in clinical Enterobacterales isolates and hypervirulent Klebsiella pneumoniae, Singapore. We collected 1,312 samples available in the CaPES collection and analyzed 1,215 whole-genome sequenced samples. We identified 2 dominant clusters with large numbers of carbapenemase-encoding plasmids; the blaKPCdominant cluster comprised pKPC2 plasmids and the blaNDM–dominant cluster pNDM1 plasmids. CaPES, Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) (Enterobacteriaceae is the former name of Enterobacterales); WGS, whole-genome sequencing.

Main Article

Page created: June 22, 2022
Page updated: July 20, 2022
Page reviewed: July 20, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external