TY - JOUR AU - Hills, Thomas AU - Sharpe, Caitlin AU - Wong, Thomas AU - Cutfield, Tim AU - Lee, Arier AU - McBride, Stephen AU - Rogers, Matthew AU - Soh, May Ching AU - Taylor, Amanda AU - Taylor, Susan AU - Thomas, Mark T1 - Fetal Loss and Preterm Birth Caused by Intraamniotic Haemophilus influenzae Infection, New Zealand T2 - Emerging Infectious Disease journal PY - 2022 VL - 28 IS - 9 SP - 1747 SN - 1080-6059 AB - Invasive Haemophilus influenzae infection during pregnancy can cause preterm birth and fetal loss, but the mechanism is unclear. We investigated 54 cases of pregnancy-associated invasive H. influenzae disease in 52 unique pregnancies in the Auckland region of New Zealand during October 1, 2008‒September 30, 2018. Intraamniotic infection was identified in 36 (66.7%) of 54 cases. Outcome data were available for 48 pregnancies. Adverse pregnancy outcomes, defined as fetal loss, preterm birth, or the birth of an infant requiring intensive/special care unit admission, occurred in 45 (93.8%) of 48 (pregnancies. Fetal loss occurred in 17 (35.4%) of 48 pregnancies, before 24 weeks’ gestation in 13 cases, and at >24 weeks’ gestation in 4 cases. The overall incidence of pregnancy-associated invasive H. influenzae disease was 19.9 cases/100,000 births, which exceeded the reported incidence of pregnancy-associated listeriosis in New Zealand. We also observed higher rates in younger women and women of Māori ethnicity. KW - Haemophilus influenzae KW - bacteria KW - intraamniotic KW - infection KW - fetal loss KW - preterm birth KW - pregnancy KW - placenta KW - bacteremia KW - sepsis KW - maternal sepsis KW - neonatal sepsis KW - sepsis in pregnancy KW - New Zealand DO - 10.3201/eid2809.220313 UR - https://wwwnc.cdc.gov/eid/article/28/9/22-0313_article ER - End of Reference