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Volume 29, Number 1—January 2023
Dispatch

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan

Irene Molina-de la Fuente1, María José Sagrado Benito1Comments to Author , Laurence Flevaud, Janet Ousley, Harriet Akello Pasquale, Ahmed Julla, Abdirashid M. Abdi, Buai Tut Chol, Bakri Abubakr, Agustín BenitoComments to Author , Cristian Casademont, Carolina Nanclares, and Pedro Berzosa
Author affiliations: Institute of Health Carlos III, Madrid, Spain (I. Molina-de la Fuente); Alcala University, Madrid (I.M. de la Fuente, A. Benito, P. Berzosa); Médecins Sans Frontières, Barcelona, Spain (M.J.S. Benito, L. Flevaud, C. Casademont, C. Nanclares); Médecins Sans Frontières, New York, New York, USA (J. Ousley); National Malaria Control Program, Ministry of Health, Juba, South Sudan (H.A. Pasquale, A. Julla); Médecins Sans Frontières, Juba (A.M. Abdi, B.T. Chol); Médecins Sans Frontières, Nairobi, Kenya (B. Abubakr); Centro de Investigación Biomedica en Red de Enfermedades Infecciosas, Madrid (A. Benito, P.J.B. Diaz)

Main Article

Figure 2

Multivariable regression model of Plasmodium falciparum pfhrp2 deletions (A), pfhrp3 deletions (B), and double deletions (C) in malaria-hyperendemic region, South Sudan. Panels A, C, and E indicate uncomplicated malaria; panels B, D, and F, severe malaria. The models combined 2 continuous variables: age of the patient, represented with different colors, and total MOI, represented in x-axis, with the binary response variable (presence of deletion). Probability of deletion (y-axis) was considered a binary outcome variable. The quality of the model was evaluated by the likelihood ratio method. The model was significant (p value<0.01) for pfhrp2 and pfhrp3 deletion and pfhrp2 and pfhrp3 double deletion. Each dot represents 1 sample. MOI, multiplicity of infection.

Figure 2. Multivariable regression model of Plasmodium falciparum pfhrp2 deletions (A), pfhrp3 deletions (B), and double deletions (C) in malaria-hyperendemic region, South Sudan. Panels A, C, and E indicate uncomplicated malaria; panels B, D, and F, severe malaria. The models combined 2 continuous variables: age of the patient, represented with different colors, and total MOI, represented in x-axis, with the binary response variable (presence of deletion). Probability of deletion (y-axis) was considered a binary outcome variable. The quality of the model was evaluated by the likelihood ratio method. The model was significant (p value<0.01) for pfhrp2 and pfhrp3 deletion and pfhrp2 and pfhrp3 double deletion. Each dot represents 1 sample. MOI, multiplicity of infection.

Main Article

1These authors contributed equally to this article.

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Page updated: December 22, 2022
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