TY - JOUR
AU - Plumb, Ian
AU - Brown, Allison
AU - Stokes, Erin
AU - Chen, Jessica
AU - Carleton, Heather
AU - Tolar, Beth
AU - Sundararaman, Preethi
AU - Saupe, Amy
AU - Payne, Daniel
AU - Shah, Hazel
AU - Folster, Jason
AU - Friedman, Cindy
T1 - Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018
T2 - Emerging Infectious Disease journal
PY - 2023
VL - 29
IS - 2
SP - 314
SN - 1080-6059
AB -
Reports of Salmonella enterica I serotype 4,[5],12:i:- infections resistant to ampicillin, streptomycin, sulphamethoxazole, and tetracycline (ASSuT) have been increasing. We analyzed data from 5 national surveillance systems to describe the epidemiology, resistance traits, and genetics of infections with this Salmonella strain in the United States. We found ASSuT-resistant Salmonella 4,[5],12:i:- increased from 1.1% of Salmonella infections during 2009–2013 to 2.6% during 2014–2018; the proportion of Salmonella 4,[5],12:i:- isolates without this resistance pattern declined from 3.1% to 2.4% during the same timeframe. Among isolates sequenced during 2015–2018, a total of 69% were in the same phylogenetic clade. Within that clade, 77% of isolates had genetic determinants of ASSuT resistance, and 16% had genetic determinants of decreased susceptibility to ciprofloxacin, ceftriaxone, or azithromycin. Among outbreaks related to the multidrug-resistant clade, 63% were associated with pork consumption or contact with swine. Preventing Salmonella 4,[5],12:i:- carriage in swine would likely avert human infections with this strain.
KW - Salmonella
KW - bacteria
KW - antimicrobial resistance
KW - food safety
KW - Salmonella 4,[5],12:i:-
KW - Salmonella Typhimurium
KW - pork
KW - molecular epidemiology
KW - United States
DO - 10.3201/eid2902.220950
UR - https://wwwnc.cdc.gov/eid/article/29/2/22-0950_article
ER - End of Reference