TY - JOUR AU - Plumb, Ian AU - Brown, Allison AU - Stokes, Erin AU - Chen, Jessica AU - Carleton, Heather AU - Tolar, Beth AU - Sundararaman, Preethi AU - Saupe, Amy AU - Payne, Daniel AU - Shah, Hazel AU - Folster, Jason AU - Friedman, Cindy T1 - Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018 T2 - Emerging Infectious Disease journal PY - 2023 VL - 29 IS - 2 SP - 314 SN - 1080-6059 AB - Reports of Salmonella enterica I serotype 4,[5],12:i:- infections resistant to ampicillin, streptomycin, sulphamethoxazole, and tetracycline (ASSuT) have been increasing. We analyzed data from 5 national surveillance systems to describe the epidemiology, resistance traits, and genetics of infections with this Salmonella strain in the United States. We found ASSuT-resistant Salmonella 4,[5],12:i:- increased from 1.1% of Salmonella infections during 2009–2013 to 2.6% during 2014–2018; the proportion of Salmonella 4,[5],12:i:- isolates without this resistance pattern declined from 3.1% to 2.4% during the same timeframe. Among isolates sequenced during 2015–2018, a total of 69% were in the same phylogenetic clade. Within that clade, 77% of isolates had genetic determinants of ASSuT resistance, and 16% had genetic determinants of decreased susceptibility to ciprofloxacin, ceftriaxone, or azithromycin. Among outbreaks related to the multidrug-resistant clade, 63% were associated with pork consumption or contact with swine. Preventing Salmonella 4,[5],12:i:- carriage in swine would likely avert human infections with this strain. KW - Salmonella KW - bacteria KW - antimicrobial resistance KW - food safety KW - Salmonella 4,[5],12:i:- KW - Salmonella Typhimurium KW - pork KW - molecular epidemiology KW - United States DO - 10.3201/eid2902.220950 UR - https://wwwnc.cdc.gov/eid/article/29/2/22-0950_article ER - End of Reference