TY - JOUR AU - Nilles, Eric AU - de St. Aubin, Michael AU - Dumas, Devan AU - Duke, William AU - Etienne, Marie Caroline AU - Abdalla, Gabriela AU - Jarolim, Petr AU - Oasan, Timothy AU - Garnier, Salome AU - Iihoshi, Naomi AU - Lopez, Beatriz AU - de la Cruz, Lucia AU - Puello, Yosanly Cornelio AU - Baldwin, Margaret AU - Roberts, Kathryn AU - Peña, Farah AU - Durski, Kara AU - Sanchez, Isaac Miguel AU - Gunter, Sarah AU - Kneubehl, Alexander AU - Murray, Kristy AU - Lino, Allison AU - Strobel, Sarah AU - Baez, Amado Alejandro AU - Lau, Colleen AU - Kucharski, Adam AU - Gutiérrez, Emily Zielinski AU - Skewes-Ramm, Ronald AU - Vasquez, Marietta AU - Paulino, Cecilia Then T1 - Monitoring Temporal Changes in SARS-CoV-2 Spike Antibody Levels and Variant-Specific Risk for Infection, Dominican Republic, March 2021–August 2022 T2 - Emerging Infectious Disease journal PY - 2023 VL - 29 IS - 4 SP - 723 SN - 1080-6059 AB - To assess changes in SARS-CoV-2 spike binding antibody prevalence in the Dominican Republic and implications for immunologic protection against variants of concern, we prospectively enrolled 2,300 patients with undifferentiated febrile illnesses in a study during March 2021–August 2022. We tested serum samples for spike antibodies and tested nasopharyngeal samples for acute SARS-CoV-2 infection using a reverse transcription PCR nucleic acid amplification test. Geometric mean spike antibody titers increased from 6.6 (95% CI 5.1–8.7) binding antibody units (BAU)/mL during March–June 2021 to 1,332 (95% CI 1,055–1,682) BAU/mL during May–August 2022. Multivariable binomial odds ratios for acute infection were 0.55 (95% CI 0.40–0.74), 0.38 (95% CI 0.27–0.55), and 0.27 (95% CI 0.18–0.40) for the second, third, and fourth versus the first anti-spike quartile; findings were similar by viral strain. Combining serologic and virologic screening might enable monitoring of discrete population immunologic markers and their implications for emergent variant transmission. KW - COVID-19 KW - coronavirus disease KW - SARS-CoV-2 KW - severe acute respiratory syndrome coronavirus 2 KW - viruses KW - respiratory infections KW - zoonoses KW - vaccine-preventable diseases KW - spike antibody KW - Dominican Republic DO - 10.3201/eid2904.221628 UR - https://wwwnc.cdc.gov/eid/article/29/4/22-1628_article ER - End of Reference