TY - JOUR AU - O’Brien, Shannon AU - Cole, Lyndsey AU - Albanese, Bernadette AU - Mahon, Allison AU - Knight, Vijaya AU - Williams, Nathan AU - Severson, Rachel AU - Burakoff, Alexis AU - Alden, Nisha AU - Dominguez, Samuel T1 - SARS-CoV-2 Seroprevalence Compared with Confirmed COVID-19 Cases among Children, Colorado, USA, May–July 2021 T2 - Emerging Infectious Disease journal PY - 2023 VL - 29 IS - 5 SP - 929 SN - 1080-6059 AB - To compare SARS-CoV-2 antibody seroprevalence among children with seropositive confirmed COVID-19 case counts (case ascertainment by molecular amplification) in Colorado, USA, we conducted a cross-sectional serosurvey during May–July 2021. For a convenience sample of 829 Colorado children, SARS-CoV-2 seroprevalence was 36.7%, compared with prevalence of 6.5% according to individually matched COVID-19 test results reported to public health. Compared with non-Hispanic White children, seroprevalence was higher among Hispanic, non-Hispanic Black, and non-Hispanic other race children, and case ascertainment was significantly lower among Hispanic and non-Hispanic Black children. This serosurvey accurately estimated SARS-CoV-2 prevalence among children compared with confirmed COVID-19 case counts and revealed substantial racial/ethnic disparities in infections and case ascertainment. Continued efforts to address racial and ethnic differences in disease burden and to overcome potential barriers to case ascertainment, including access to testing, may help mitigate these ongoing disparities. KW - COVID-19 KW - 2019 novel coronavirus disease KW - coronavirus disease KW - severe acute respiratory syndrome coronavirus 2 KW - SARS-CoV-2 KW - SARS-CoV-2 infection KW - viruses KW - respiratory infections KW - zoonoses KW - 2019 novel coronavirus infection KW - 2019-nCoV KW - pandemic KW - serologic testing KW - antibody testing KW - diagnostic testing KW - Colorado KW - United States DO - 10.3201/eid2905.221541 UR - https://wwwnc.cdc.gov/eid/article/29/5/22-1541_article ER - End of Reference