Volume 3, Number 3—September 1997
Synopsis
Borna Disease Virus Infection in Animals and Humans
Jürgen A. Richt*
, Isolde Pfeuffer*, Matthias Christ*, Knut Frese†, Karl Bechter‡, and Sibylle Herzog*
, Isolde Pfeuffer*, Matthias Christ*, Knut Frese†, Karl Bechter‡, and Sibylle Herzog*
Table 1
Adoptive transfer of Borna disease virus (BDV) TH1 cells before and after BDV infection
| Group | CY treatment | Transfer of TH1-cells | Clinical BD |
|---|---|---|---|
| Control | yes | day +10 | no |
| BDV | yes | no | no |
| BDV | no | day +10 | yes |
| BDV | yes | day +3 | yes |
| BDV | yes | day +10 | yes |
| BDV | no | day -25 and -5 | no |
Four-week-old Lewis rats were inoculated intracerebrally with BDV; some rats were treated with cyclophosphamide (CY) (150 mg/kg) for immunosuppression 24 hours later. Animals were intravenously injected with >2x106 BDV-specific TH1 cells on the indicated days, either before (-) or after (+) infection with BDV.
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