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Volume 5, Number 5—October 1999

Influence of Host Genetics on the Severity of Coccidioidomycosis

Leslie Louie*Comments to Author , Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*
Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA

Main Article

Table 3

Blood group antigen frequencies for coccidioidomycosis, by ethnicity and severity of disease

Ethnic group A AB B O N
Hispanica Severe 0.24 0.02 0.12 0.62 50
Mild 0.53 0.00 0.00 0.47 32
Controlsb 0.13 0.04 0.27 0.56 335
Caucasian Severe 0.48 0.04 0.04 0.44 27
Mild 0.46 0.02 0.12 0.40 50
Controlsb 0.41 0.03 0.11 0.45 8,962
African- Severe 0.12 0.04 0.16 0.68 25
American Controlsb 0.28 0.04 0.19 0.50 1,540

aABO phenotype distribution for cases and controls among Hispanics, p < 0.001
bPopulation control frequencies from Mourant, 1976 (17)

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  1. Pappagianis  D, Sun  RK, Werner  SB, Rutherford  GW, Elsea  RW, Miller  GB, CoccidioidomycosisUnited States, 1991-1992. MMWR Morb Mortal Wkly Rep. 1993;42:214.PubMedGoogle Scholar
  2. Pappagianis  D. Marked increase in cases of coccidioidomycosis in California: 1991, 1992, and 1993. Clin Infect Dis. 1994;19(Suppl 1):S148.PubMedGoogle Scholar
  3. Pappagianis  D, Feldman  G, Billimek  M, Mascola  L, Werner  SB, Jackson  RJ, Coccidioidomycosis following the Northridge earthquake—California, 1994. MMWR Morb Mortal Wkly Rep. 1994;43:1945.PubMedGoogle Scholar
  4. Jinadu  BA, Welch  G, Talbot  R, Caldwell  J, Johnson  R, Blume  D, Coccidioidomycosis—California, 1991-1993. MMWR Morb Mortal Wkly Rep. 1994;43:4213.PubMedGoogle Scholar
  5. Schneider  E, Hajjeh  RA, Spiegel  RA, Jibson  RW, Harp  EL, Marshall  GA, A coccidioidomycosis outbreak following the Northridge, Calif, earthquake. JAMA. 1997;277:9048. DOIPubMedGoogle Scholar
  6. Galgiani  JN, Cohen  IM. Coccidioidomycosis in renal transplant recipients: blood group, diabetes, and tissue type as risk factors. Current chemotherapy and infectious disease. Proceedings of the 11th International Congress of Chemotherapy and the 19th Interscience Conference on Antimicrobial Agents and Chemotherapy. Boston (MA): American Society for Microbiology; 1980. p. 992-4.
  7. Cohen  IM, Galgiani  JN, Potter  D, Ogden  DA. Coccidioidomycosis in renal replacement therapy. Arch Intern Med. 1982;142:48994. DOIPubMedGoogle Scholar
  8. Galgiani  JN. Coccidioidomycosis. West J Med. 1993;159:15371.PubMedGoogle Scholar
  9. Pappagianis  D. Epidemiology of coccidioidomycosis. In: McGinnis M, editor. Current topics in medical mycology. New York: Springer Verlag; 1988. p. 199-238.
  10. Flynn  NM, Hoeprich  PD, Kawachi  MM, Lee  KK, Lawrence  RM, Goldstein  E, An unusual outbreak of windborne coccidioidomycosis. N Engl J Med. 1979;301:35861.PubMedGoogle Scholar
  11. Rosenstein  N, Werner  SB, Kao  A, Emery  K, Rogers  D, Vugia  D, Coccidioidomycosis: risk factors for severe pulmonary and disseminated disease. Kern County, California. Proceedings of the 35th Annual Meeting of the Infectious Diseases Society of America; 1997 Sept 13-17; San Francisco, California; 1997.
  12. Catanzaro  A, Spitler  LE, Moser  KM. Cellular immune response in coccidioidomycosis. Cell Immunol. 1975;15:36071. DOIPubMedGoogle Scholar
  13. Cox  RA, Vivas  JR, Gross  A, Lecara  G, Miller  E, Brummer  E. In vivo and in vitro cell-mediated responses in coccidioidomycosis. I. Immunologic responses of persons with primary, asymptomatic infections. Am Rev Respir Dis. 1976;114:93743.PubMedGoogle Scholar
  14. Mosmann  TR, Coffman  RL. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol. 1989;46:11147. DOIPubMedGoogle Scholar
  15. Scheer  M, Opelz  G, Terasaki  P, Hewitt  W. The association of disseminated coccidioidomycosis and histocompatibility type. Proceedings of the 13th Interscience Conference on Antimicrobial Agents and Chemotherapy. 1973; Washington: American Society for Microbiology; 1973.
  16. Deresinski  SC, Pappagianis  D, Stevens  DA. Association of ABO blood group and outcome of coccidioidal infection. Sabouraudia. 1979;17:2614.PubMedGoogle Scholar
  17. Mourant  AE, Kopec  AC, Domaniewska-Sobczak  K. The distribution of the human blood groups, and other poly-morphisms. London: Oxford University Press; 1976. p. 230.
  18. Barcellos  LF. Genetic analysis of multiple sclerosis in Caucasian and Northern Chinese populations: An investigation of HLA and non-HLA loci. School of Public Health [dissertation]. Berkeley (CA): University of California; 1996.
  19. Erlich  HA, Zeidler  A, Chang  J, Shaw  S, Raffel  LJ, Klitz  W, HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Nat Genet. 1993;3:35864. DOIPubMedGoogle Scholar
  20. Just  JJ, King  MC, Thomson  G, Klitz  W. African-American HLA class II allele and haplotype diversity. Tissue Antigens. 1997;49:54755. DOIPubMedGoogle Scholar
  21. Miller  SA, Dykes  DD, Polesky  HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215. DOIPubMedGoogle Scholar
  22. Erlich  H, Bugawan  T, Begovich  AB, Scharf  S, Griffith  R, Saiki  R, HLA-DR, DQ and DP typing using PCR amplification and immobilized probes. Eur J Immunogenet. 1991;18:3355. DOIPubMedGoogle Scholar
  23. Carrington  M, Miller  T, White  M, Gerrard  B, Stewart  C, Dean  M, Typing of HLA-DQA1 and DQB1 using DNA single-strand conformation polymorphism. Hum Immunol. 1992;33:20812. DOIPubMedGoogle Scholar
  24. Olerup  O, Aldener  A, Fogdell  A. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens. 1993;41:11934. DOIPubMedGoogle Scholar
  25. Guo  SW, Thompson  EA. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics. 1992;48:36172. DOIPubMedGoogle Scholar
  26. Vogel  F, Motulsky  AG. Human Genetics. Berlin: Springer Verlag; 1986. p. 130-1.
  27. Baur  MP, Danilovs  J. Population genetic analysis of HLA-A, B, C, DR, and other genetic markers. In: Terasaki PI, editor. Histocompatibility testing 1980. Los Angeles: UCLA Tissue Typing Laboratory; 1980. p. 955-93.
  28. Long  JC, Williams  RC, Urbanek  M. An E-M algorithm and testing strategy for multiple-locus haplotypes. Am J Hum Genet. 1995;56:799810.PubMedGoogle Scholar
  29. U.S. Department of Health and Human Services. United States 1996-1997 health and injury chartbook. Hyattsville (MD): The Department; 1997. Pub. no. (PHS) 97-1232.
  30. Race  RR, Sanger  R. Blood groups in man. Oxford (PA): Blackwell Scientific Publications distributed by J. B. Lippincott; 1975.
  31. Reid  ME, Bird  GW. Associations between human red cell blood group antigens and disease. Transfus Med Rev. 1990;4:4755.PubMedGoogle Scholar
  32. Yamamoto  F, Clausen  H, White  T, Marken  J, Hakomori  S. Molecular genetic basis of the histo-blood group ABO system. Nature. 1990;345:22933. DOIPubMedGoogle Scholar
  33. Gale  D, Lockhart  EA, Kimbell  E. Studies of Coccidioides immitis. 4. The effect of previous injection with human red cell stromata of the ABO groups on infection of mice with C. immitis. J Infect Dis. 1968;118:5464.PubMedGoogle Scholar
  34. Greggio  NA, Cameran  M, Giaquinto  C, Zacchello  F, Koroliuk  D, Colizzi  V. DNA HLA-DRB1 analysis in children of positive mothers and estimated risk of vertical HIV transmission. Dis Markers. 1993;11:2935.PubMedGoogle Scholar
  35. Winchester  R, Chen  Y, Rose  S, Selby  J, Borkowsky  W. Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method. Proc Natl Acad Sci U S A. 1995;92:123748. DOIPubMedGoogle Scholar
  36. Chen  Y, Winchester  R, Korber  B, Gagliano  J, Bryson  Y, Hutto  C, Influence of HLA alleles on the rate of progression of vertically transmitted HIV infection in children: association of several HLA-DR13 alleles with long-term survivorship and the potential association of HLA-A*2301 with rapid progression to AIDS. Long-term survivor study. Hum Immunol. 1997;55:15462. DOIPubMedGoogle Scholar
  37. Tiwari  JL, Terasaki  PI, eds. HLA and disease associations. New York: Springer Verlag; 1985.
  38. Serjeantson  SW, Easteal  S. Class II histocompatibility genes and insulin-dependent diabetes mellitus. Mol Biol Med. 1989;6:21926.PubMedGoogle Scholar
  39. Kirkland  TN, Finley  F, Orsborn  KI, Galgiani  JN. Evaluation of the proline-rich antigen of Coccidioides immitis as a vaccine candidate in mice. Infect Immun. 1998;66:351922.PubMedGoogle Scholar
  40. Kirkland  TN, Thomas  PW, Finley  F, Cole  GT. Immunogenicity of a 48-kilodalton recombinant T-cell-reactive protein of Coccidioides immitis. Infect Immun. 1998;66:42431.PubMedGoogle Scholar
  41. Zimmermann  CR, Johnson  SM, Martens  GW, White  AG, Zimmer  BL, Pappagianis  D. Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules. Infect Immun. 1998;66:23425.PubMedGoogle Scholar

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