Influence of Host Genetics on the Severity of Coccidioidomycosis
Leslie Louie*

, Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*
Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA
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Table 4
Significance levels from contingency table analyses of allele distributions for by ethnicity and severity of coccidioidomycosis, diseasea
Ethnic group |
Locus. |
Severe vs mild |
Severe vs control |
Mild vs control |
Caucasian |
DQA1 |
0.231 |
0.069 |
0.048 |
|
DQB1 |
0.024 |
0.02 |
0.002 |
|
DRB1 |
0.075 |
0.12 |
<0.001 |
|
DR-DQ |
0.031 |
<0.001 |
<0.001 |
|
DPB1 |
0.781 |
0.215 |
0.355 |
Hispanics |
DQA1 |
0.074 |
— |
— |
|
DQB1 |
0.41 |
0.003 |
0.16 |
|
DRB1 |
0.63 |
<0.001 |
0.16 |
|
DR-DQ |
0.29 |
<0.001 |
0.02 |
|
DPB1 |
0.024 |
0.403 |
0.026 |
African- |
DQA1 |
— |
0.89 |
— |
Americans |
DQB1 |
— |
0.34 |
— |
|
DRB1 |
— |
0.001 |
— |
|
DR-DQ |
— |
<0.001 |
— |
|
DPB1 |
— |
0.38 |
— |
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Page created: December 15, 2010
Page updated: December 15, 2010
Page reviewed: December 15, 2010
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