To the Editor: The recent article by Meltzer and colleagues (1) is an important contribution to a pertinent public health issue: who should receive the newly licensed Lyme disease vaccine. Answering this question is a daunting task, given the scarcity of valid data. Estimates of the spectrum and prevalence of the long-term sequelae of Lyme disease remain controversial (2-4). In generating their cost-effectiveness model, Meltzer et al. examined the cost savings involved in preventing three categories of classic organ-specific Lyme disease sequelae (cardiovascular, neurologic, and arthritic); however, they did not take into account the potential cost savings from preventing cases of a generalized symptom complex known as post-Lyme syndrome, which includes persisting myalgia, arthralgia, headache, fatigue, and neurocognitive deficits. These generalized sequelae, which are recognized by the National Institutes of Health as late sequelae of Lyme disease, have been found to persist for years after antibiotic therapy (5,6). Two population-based retrospective cohort studies (7,8) among Lyme disease patients whose illness was diagnosed in the mid-1980s determined that one third to half had clinically corroborated post-Lyme syndrome symptoms years after the initial onset of disease. Although these studies were conducted 15 years ago, when optimal antibiotic regimen guidelines were still evolving, the estimated cost of averting these often-disabling nonorgan-specific symptoms should also be taken into account in estimated sensitivity analyses of vaccine cost-effectiveness. The cost of treating sequelae is weighted heavily in the cost-effectiveness models presented by Meltzer and colleagues, which adds importance to considering post-Lyme syndrome. Nevertheless, we recognize the difficulty of this modeling, especially in the absence of validated cost-of-treatment data for these generalized symptoms.

A point of correction is that Meltzer et al. erroneously cite one of these studies (7) to infer that the long-term clinical sequelae of Lyme disease lasted a mean of 6.2 years from the onset of disease. In this retrospective study, Shadick et al. evaluated 38 persons with a clinical history of Lyme disease a mean of 6.2 years from the onset of disease regardless of the presence of persisting symptoms; 25 of these patients had no residual symptoms at follow-up. To accurately estimate the duration of clinical sequelae, longitudinal evaluations of representative populations of Lyme disease patients will be required because late manifestations have been demonstrated months to years after diagnosis (9,10).

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